The herpes simplex virus type 1 (HSV-1) genome is contained in a capsid wrapped by a
complex tegument layer and an external envelope. The poorly defined tegument plays a …

Primary envelopment of several herpesviruses has been shown to occur by budding of
intranuclear capsids through the inner nuclear membrane. By subsequent fusion of the …

In herpes simplex virus-infected cells, viral γ134. 5 protein blocks the shutoff of protein
synthesis by activated protein kinase R (PKR) by directing the protein phosphatase 1α to …

Herpes simplex virus (HSV) glycoprotein K (gK) is thought to be intimately involved in the
process by which infected cells fuse because HSV syncytial mutations frequently alter the gK …

Earlier studies have shown that the Golgi apparatus was fragmented and dispersed in
herpes simplex virus 1-infected Vero and HEp-2 cells but not in human 143TK-cells, that the …

Pseudorabies virus (PRV), a member of the Alphaherpesvirinae, has a complex multilayered
extracellular virion that is structurally conserved among other herpesviruses. PRV virions …

The herpes simplex virus type 1 γ134. 5 gene product precludes the host-mediated protein
shutoff response induced by activated protein kinase R (PKR). Earlier studies demonstrated …

We characterized the glycoprotein K (gK)-null herpes simplex virus type 1 [HSV-1](KOS)
delta gK and compared it to the gK-null virus HSV-1 F-gKbeta (L. Hutchinson et al., J. Virol …

Previous studies have shown that a ts mutant [herpes simplex virus 1 (mP) ts66. 4] in the
UL15 gene fails to package viral DNA into capsids (APW Poon and B. Roizman, J. Virol. 67 …

Final envelopment of the cytoplasmic herpes simplex virus type 1 (HSV-1) nucleocapsid is
thought to occur by budding into trans-Golgi network (TGN)-derived membranes. The highly …