Development of polymeric nanoparticles for blood–brain barrier transfer—strategies and challenges
Neurological disorders such as Alzheimer's disease, stroke, and brain cancers are difficult to
treat with current drugs as their delivery efficacy to the brain is severely hampered by the …
treat with current drugs as their delivery efficacy to the brain is severely hampered by the …
[HTML][HTML] Challenges and opportunities to penetrate the blood-brain barrier for brain cancer therapy
DH Upton, C Ung, SM George, M Tsoli, M Kavallaris… - Theranostics, 2022 - ncbi.nlm.nih.gov
Despite significant advances in research, the prognosis for both primary and secondary
brain cancers remains poor. The blood-brain barrier (BBB) is a complex and unique semi …
brain cancers remains poor. The blood-brain barrier (BBB) is a complex and unique semi …
Glutathione: antioxidant properties dedicated to nanotechnologies
C Gaucher, A Boudier, J Bonetti, I Clarot, P Leroy… - Antioxidants, 2018 - mdpi.com
Which scientist has never heard of glutathione (GSH)? This well-known low-molecular-
weight tripeptide is perhaps the most famous natural antioxidant. However, the interest in …
weight tripeptide is perhaps the most famous natural antioxidant. However, the interest in …
Central nervous system toxicity of metallic nanoparticles
X Feng, A Chen, Y Zhang, J Wang… - International journal of …, 2015 - Taylor & Francis
Nanomaterials (NMs) are increasingly used for the therapy, diagnosis, and monitoring of
disease-or drug-induced mechanisms in the human biological system. In view of their small …
disease-or drug-induced mechanisms in the human biological system. In view of their small …
From cells to organoids: The evolution of blood-brain barrier technology for modelling drug delivery in brain cancer
E Gonzales-Aloy, A Ahmed-Cox, M Tsoli… - Advanced Drug Delivery …, 2023 - Elsevier
Brain cancer remains the deadliest cancer. The blood–brain barrier (BBB) is impenetrable to
most drugs and is a complex 3D network of multiple cell types including endothelial cells …
most drugs and is a complex 3D network of multiple cell types including endothelial cells …
An insight to brain targeting utilizing polymeric nanoparticles: effective treatment modalities for neurological disorders and brain tumor
The delivery of therapeutic molecules to the brain remains an unsolved problem to the
researchers due to the existence of the blood–brain barrier (BBB), which halts the entry of …
researchers due to the existence of the blood–brain barrier (BBB), which halts the entry of …
Biopolymer nanoparticles for nose-to-brain drug delivery: A new promising approach for the treatment of neurological diseases
Diseases affecting the central nervous system (CNS) are among the most disabling and the
most difficult to cure due to the presence of the blood–brain barrier (BBB) which represents …
most difficult to cure due to the presence of the blood–brain barrier (BBB) which represents …
Design and development of nanomaterial-based drug carriers to overcome the blood–brain barrier by using different transport mechanisms
Central nervous system (CNS) diseases are the leading causes of death and disabilities in
the world. It is quite challenging to treat CNS diseases efficiently because of the blood–brain …
the world. It is quite challenging to treat CNS diseases efficiently because of the blood–brain …
Surface engineered polymeric nanocarriers mediate the delivery of transferrin–methotrexate conjugates for an improved understanding of brain cancer
The objective of present study was to enhance permeation of bioactive molecules across
blood brain barrier (BBB) through polysorbate 80 coated poly-lactic-co-glycolic acid (PLGA) …
blood brain barrier (BBB) through polysorbate 80 coated poly-lactic-co-glycolic acid (PLGA) …
Technical aspects of preparing PEG-PLGA nanoparticles as carrier for chemotherapeutic agents by nanoprecipitation method
Nanoprecipitation is a simple and increasingly trending method for nanoparticles
preparation. The self-assembly feature of poly (ethylene glycol)-poly (lactide-co-glycolic …
preparation. The self-assembly feature of poly (ethylene glycol)-poly (lactide-co-glycolic …