The Wnt signaling pathway plays important roles in embryonic development, homeostatic
processes, cell differentiation, cell polarity, cell proliferation, and cell migration via the β …

Ubiquitination represents a post-translational modification (PTM) essential for the
maintenance of cellular homeostasis. Ubiquitination is involved in the regulation of protein …

Our understanding of the highly specialized functions for small non-coding single-stranded
RNA (ssRNA) in the transcriptome of the human central nervous system (CNS) continues to …

Pancreatic cancer stem cells (PaCSCs) drive pancreatic cancer tumorigenesis,
chemoresistance and metastasis. While eliminating this subpopulation of cells would …

Cancer is a disorder of cell growth and proliferation, characterized by different metabolic
pathways within normal cells. The Warburg effect is a major metabolic process in cancer …

Abstract Polycomb repressive complex 2 (PRC2) is a chromatin-modifying enzyme that
catalyses the methylation of histone H3 at lysine 27 (H3K27me1/2/3). This complex …

Cancer is one of the lethal diseases that arise due to the molecular alterations in the cell.
One of those alterations associated with cancer corresponds to differential expression of …

Cancer stem cells (CSCs) exhibit highly aggressive and metastatic features and resistance
to chemotherapy and radiotherapy. Aryl hydrocarbon receptor (AhR) expression varies …

Ubiquitination is a key enzymatic post-translational modification that influences p53 stability
and function. p53 protein regulates the expression of MDM2 (mouse double-minute 2 …

Background Bladder cancer (BCa) is one of the most prevalent malignancies globally.
Previous study has reported the inhibitory effect of methyltransferase-like 14 (METTL14) on …