1, 2, 3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview

K Bozorov, J Zhao, HA Aisa - Bioorganic & medicinal chemistry, 2019 - Elsevier
Abstract The 1, 2, 3-triazole ring is a major pharmacophore system among nitrogen-
containing heterocycles. These five-membered heterocyclic motifs with three nitrogen …

[HTML][HTML] Recent advances in chalcone-triazole hybrids as potential pharmacological agents

A Bhukal, V Kumar, LK Kumar, K Lal - Results in Chemistry, 2023 - Elsevier
Molecular hybridization is one of the recent strategies to synthesize a novel hybrid
compound by combining two or more pharmacophoric units. Being a linkage process, it …

Synthesis, characterization, and antioxidant and anticancer activity of 1, 4-disubstituted 1, 2, 3-triazoles

İ Şahin, FB Özgeriş, M Köse, E Bakan… - Journal of Molecular …, 2021 - Elsevier
This manuscript describes the synthesis, characterization, antioxidant and anticancer
activities of the six 1, 2, 3-triazole derivatives (7a, 7b, 8a, 8b, 9a and 9b) containing a 1, 4 …

Benzimidazole and piperidine containing novel 1, 2, 3‐triazole hybrids as anti‐infective agents: Design, synthesis, in silico and in vitro antimicrobial efficacy

JV Mendapara, MD Vaghasiya… - … of Biochemical and …, 2024 - Wiley Online Library
Cu alkyne‐azide cycloaddition was used to easily synthesize a library of novel heterocycles
containing benzimidazole and piperidine based 1, 2, 3‐triazole (7a–7l) derivatives. The …

One‐pot synthesis and biological evaluation of novel 4‐[3‐fluoro‐4‐(morpholin‐4‐yl)]phenyl‐1H‐1,2,3‐triazole derivatives as potent antibacterial and anticancer …

S Narsimha, SK Nukala… - Journal of …, 2020 - Wiley Online Library
In search of better antibacterial and anticancer agents, a series of novel 4‐[3‐fluoro‐4‐
(morpholin‐4‐yl)] phenyl‐1 H‐1, 2, 3‐triazole derivatives were synthesized (6a‐l and 8a‐j) …

[HTML][HTML] Triazole, imidazole, and thiazole-based compounds as potential agents against coronavirus

I Seck, F Nguemo - Results in chemistry, 2021 - Elsevier
The expansion of the novel coronavirus known as SARS-CoV-2 (severe acute respiratory
syndrome coronavirus 2), COVID-19 (coronavirus disease 2019), or 2019-nCoV (2019 novel …

Design, synthesis and biological evaluation of novel 1, 2, 3-triazole-based xanthine derivatives as DPP-4 inhibitors

S Narsimha, KS Battula, M Ravinder, YN Reddy… - Journal of Chemical …, 2020 - Springer
Inhibitors of dipeptidyl peptidase-4 (DPP4) have been shown to be effective treatments for
type 2 diabetes. A series of novel 1, 2, 3-triazole based xanthine derivatives were designed …

Microwave-assisted Cu-catalyzed C–C bond formation: one-pot synthesis of fully substituted 1, 2, 3-triazoles using nonsymmetrical iodoalkynes and their biological …

S Narsimha, KS Battula, YN Reddy… - Chemistry of Heterocyclic …, 2018 - Springer
A copper-catalyzed one-pot synthesis of fused benzothiazino [1, 2, 3] triazolo [4, 5-c]
quinolinone derivatives from 1-iodoalkynes with different aryl azides via an in situ generated …

Organocatalytic [3+ 2] Cycloaddition reaction: synthesis of fully decorated sulfonyl-1, 2, 3-triazolyl pyrimidines as potent anticancer and EGFR inhibitors

JMR Velidandla, SK Koppula - Polycyclic Aromatic Compounds, 2024 - Taylor & Francis
A general strategy was developed for the synthesis of new fully decorated sulfonyl1, 2, 3-
triazolyl pyrimidines (6a–6j and 8a–8f) from 2-((6-methyl-2-(methylsulfonyl) pyrimidin-4-yl) …

Organocatalytic [3+ 2] Cycloaddition Reaction: Synthesis of Fully Decorated Sulfonyl 1, 2, 3‐Triazoles as Potent EGFR Targeting Anticancer Agents

V Reddy Dodlapati, T Madhukar Reddy… - …, 2023 - Wiley Online Library
A general strategy was developed for the synthesis of new fully decorated sulfonyl1, 2, 3‐
triazolyl imidazoles from β‐ketosulfones and several aryl sulfonyl azides using the …