Background: Given the common elements in the pathophysiological theories that try to
explain the appearance and evolution of obesity and multiple sclerosis, the association …

Protein S-palmitoylation refers to a post-translational modification (PTM) wherein palmitic
acid, a 16-carbon long saturated fatty acid gets covalently attached to Cys sidechain of a …

Previous studies confirmed that dietary supplements of fish oil and krill oil can alleviate
obesity in mice, but the underlying mechanism remains unclear. This study aims to discern …

Metabolic syndrome is a key risk factor and co-morbidity in multiple sclerosis (MS) and other
neurological conditions, such that a better understanding of how a high fat diet contributes to …

β-Site APP-cleaving enzyme 1 (BACE1) inhibition is considered one of the most promising
therapeutic strategies for Alzheimer's disease, but current BACE1 inhibitors also block …

Puberty is a dynamic period marked by changing levels of sex hormones, the development
of secondary sexual characteristics and reproductive maturity. This period has profound …

Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous
system (CNS) that affects 2.5 million people worldwide [1]. There is currently no cure for MS; …

The experimental autoimmune encephalomyelitis mouse model is the most commonly used
animal model, and it best represents multiple sclerosis. Grancalcin (GCA) was discovered to …

Cells of the adaptive and innate immune systems in the brain parenchyma and in the
meningeal spaces contribute to physiologic functions and disease states in the central …

Experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis
(MS), approximates the key histopathological, clinical, and immunological features of MS …