The ubiquitin-proteasome pathway (UPP) is involved in regulating several biological
functions, including cell cycle control, apoptosis, DNA damage response, and apoptosis. It is …

Polymeric micelles (PMs) play a vital role in multidrug co-delivery and cancer treatment.
However, development of intelligent PMs further allows PMs to accurately target tumour …

Ubiquitin-conjugating enzyme E2C (UBE2C) mediates ubiquitylation chain formation via the
K11 linkage. While previous in vitro studies showed that UBE2C plays a growth-promoting …

Diseases at the molecular level are complex and patient dependent, necessitating
development of strategies that enable precision treatment to optimize clinical outcomes …

Ubiquitination-related genes (URGs) exerted a crucial part in a variety of human disease
disorders; however, their association with pancreatic adenocarcinoma (PAAD) had yet to be …

Ubiquitination is one of the main post-translational modification of proteins. It plays key roles
in a broad range of cellular functions, including protein degradation, protein interactions …

Background: Ubiquitin-conjugating enzyme E2C (UBE2C) has been shown to be associated
with the occurrence of various cancers and involved in many tumorigenic processes. This …

Glioblastoma (GB) and brain metastases (BM) are the most common brain tumors in adults
and are invariably associated with a dismal outcome. These highly malignant tumors share …

The ubiquitin-conjugating enzyme 2C (UBE2C) is the key component in the ubiquitin
proteasome system (UPS) by partnering with the anaphase‑promoting complex (APC/C). A …

Oocytes develop the competence for meiosis and early embryogenesis during their growth.
Setdb1 is a histone H3 lysine 9 (H3K9) methyltransferase required for post-implantation …