Oxidative stress is known to play an important role in the pathogenesis of a number of
diseases. In particular, it is linked to the etiology of Alzheimer's disease (AD), an age-related …

Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …

The basic role of metal ions including copper, zinc and iron in neurological pathologies is
generally accepted. The relationship between the development of disease and particular …

Copper is a redox-active metal with many important biological roles. Consequently, its
distribution and oxidation state are subject to stringent regulation. A large body of …

Metal ions, mainly copper, zinc and iron, have been involved in several processes
associated with the etiology of Alzheimer disease (AD). Amyloid deposits found in AD …

Peptides are versatile and powerful ligands to form stable complexes with the great majority
of metal ions. The outstanding stability of peptide complexes is, however, linked to the …

Carnosine (β-alanyl-l-histidine) is a natural dipeptide widely and abundantly distributed in
excitable tissues of several animal tissues. Although its physiological role has not been …

In this perspective we list the many clinical, histopathological, genetic and chemical
observations relating copper to Alzheimer's disease (AD). We summarize how the …

The review describes the state of the art in the field of stability constant determination for Cu
(II), Cu (I) and Zn (II) complexes of proteins and peptides involved in neurodegenerative …