[HTML][HTML] Oxidative stress and the amyloid beta peptide in Alzheimer's disease
C Cheignon, M Tomas, D Bonnefont-Rousselot… - Redox biology, 2018 - Elsevier
Oxidative stress is known to play an important role in the pathogenesis of a number of
diseases. In particular, it is linked to the etiology of Alzheimer's disease (AD), an age-related …
diseases. In particular, it is linked to the etiology of Alzheimer's disease (AD), an age-related …
Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Bioinorganic chemistry of Alzheimer's disease
KP Kepp - Chemical reviews, 2012 - ACS Publications
Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …
of all cases), associated with loss of memory (in particular episodic memory), cognitive …
Copper, zinc and iron in neurodegenerative diseases (Alzheimer's, Parkinson's and prion diseases)
H Kozlowski, M Luczkowski, M Remelli… - Coordination Chemistry …, 2012 - Elsevier
The basic role of metal ions including copper, zinc and iron in neurological pathologies is
generally accepted. The relationship between the development of disease and particular …
generally accepted. The relationship between the development of disease and particular …
Copper and oxidative stress in the pathogenesis of Alzheimer's disease
G Eskici, PH Axelsen - Biochemistry, 2012 - ACS Publications
Copper is a redox-active metal with many important biological roles. Consequently, its
distribution and oxidation state are subject to stringent regulation. A large body of …
distribution and oxidation state are subject to stringent regulation. A large body of …
Coordination of redox active metal ions to the amyloid precursor protein and to amyloid-β peptides involved in Alzheimer disease. Part 1: An overview
C Hureau - Coordination Chemistry Reviews, 2012 - Elsevier
Metal ions, mainly copper, zinc and iron, have been involved in several processes
associated with the etiology of Alzheimer disease (AD). Amyloid deposits found in AD …
associated with the etiology of Alzheimer disease (AD). Amyloid deposits found in AD …
Peptides as complexing agents: Factors influencing the structure and thermodynamic stability of peptide complexes
Peptides are versatile and powerful ligands to form stable complexes with the great majority
of metal ions. The outstanding stability of peptide complexes is, however, linked to the …
of metal ions. The outstanding stability of peptide complexes is, however, linked to the …
Neuroprotective features of carnosine in oxidative driven diseases
Carnosine (β-alanyl-l-histidine) is a natural dipeptide widely and abundantly distributed in
excitable tissues of several animal tissues. Although its physiological role has not been …
excitable tissues of several animal tissues. Although its physiological role has not been …
Copper imbalance in Alzheimer's disease: Convergence of the chemistry and the clinic
In this perspective we list the many clinical, histopathological, genetic and chemical
observations relating copper to Alzheimer's disease (AD). We summarize how the …
observations relating copper to Alzheimer's disease (AD). We summarize how the …
Affinity of copper and zinc ions to proteins and peptides related to neurodegenerative conditions (Aβ, APP, α-synuclein, PrP)
I Zawisza, M Rózga, W Bal - Coordination Chemistry Reviews, 2012 - Elsevier
The review describes the state of the art in the field of stability constant determination for Cu
(II), Cu (I) and Zn (II) complexes of proteins and peptides involved in neurodegenerative …
(II), Cu (I) and Zn (II) complexes of proteins and peptides involved in neurodegenerative …