Bacterial persisters: molecular mechanisms and therapeutic development
H Niu, J Gu, Y Zhang - Signal transduction and targeted therapy, 2024 - nature.com
Persisters refer to genetically drug susceptible quiescent (non-growing or slow growing)
bacteria that survive in stress environments such as antibiotic exposure, acidic and …
bacteria that survive in stress environments such as antibiotic exposure, acidic and …
Multidrug efflux pumps: structure, function and regulation
Infections arising from multidrug-resistant pathogenic bacteria are spreading rapidly
throughout the world and threaten to become untreatable. The origins of resistance are …
throughout the world and threaten to become untreatable. The origins of resistance are …
Antidepressants can induce mutation and enhance persistence toward multiple antibiotics
Antibiotic resistance is an urgent threat to global health. Antidepressants are consumed in
large quantities, with a similar pharmaceutical market share (4.8%) to antibiotics (5%). While …
large quantities, with a similar pharmaceutical market share (4.8%) to antibiotics (5%). While …
Recovery of gut microbiota of healthy adults following antibiotic exposure
To minimize the impact of antibiotics, gut microorganisms harbour and exchange antibiotics
resistance genes, collectively called their resistome. Using shotgun sequencing-based …
resistance genes, collectively called their resistome. Using shotgun sequencing-based …
Persistent bacterial infections and persister cells
RA Fisher, B Gollan, S Helaine - Nature Reviews Microbiology, 2017 - nature.com
Many bacteria can infect and persist inside their hosts for long periods of time. This can be
due to immunosuppression of the host, immune evasion by the pathogen and/or ineffective …
due to immunosuppression of the host, immune evasion by the pathogen and/or ineffective …
Mechanisms of bacterial persistence during stress and antibiotic exposure
A Harms, E Maisonneuve, K Gerdes - Science, 2016 - science.org
BACKGROUND The escalating crisis of multidrug resistance is raising fears of untreatable
infections caused by bacterial “superbugs.” However, many patients already suffer from …
infections caused by bacterial “superbugs.” However, many patients already suffer from …
ATP-dependent dynamic protein aggregation regulates bacterial dormancy depth critical for antibiotic tolerance
Y Pu, Y Li, X Jin, T Tian, Q Ma, Z Zhao, S Lin, Z Chen… - Molecular cell, 2019 - cell.com
Cell dormancy is a widespread mechanism used by bacteria to evade environmental
threats, including antibiotics. Here we monitored bacterial antibiotic tolerance and regrowth …
threats, including antibiotics. Here we monitored bacterial antibiotic tolerance and regrowth …
Artificial sweeteners stimulate horizontal transfer of extracellular antibiotic resistance genes through natural transformation
Antimicrobial resistance has emerged as a global threat to human health. Natural
transformation is an important pathway for horizontal gene transfer, which facilitates the …
transformation is an important pathway for horizontal gene transfer, which facilitates the …
Formation, physiology, ecology, evolution and clinical importance of bacterial persisters
B Van den Bergh, M Fauvart… - FEMS microbiology …, 2017 - academic.oup.com
Persisters are transiently tolerant variants that allow populations to avoid eradication by
antibiotic treatment. Their antibiotic tolerance is non-genetic, not inheritable and results from …
antibiotic treatment. Their antibiotic tolerance is non-genetic, not inheritable and results from …
Acinetobacter baumannii Efflux Pumps and Antibiotic Resistance
SN Abdi, R Ghotaslou, K Ganbarov… - Infection and drug …, 2020 - Taylor & Francis
Acinetobacter baumannii is a nosocomial pathogen and gram-negative coccobacillus that is
responsible for opportunistic infections, pneumonia, and infections of the urinary tract …
responsible for opportunistic infections, pneumonia, and infections of the urinary tract …