Bacterial persisters: molecular mechanisms and therapeutic development

H Niu, J Gu, Y Zhang - Signal transduction and targeted therapy, 2024 - nature.com
Persisters refer to genetically drug susceptible quiescent (non-growing or slow growing)
bacteria that survive in stress environments such as antibiotic exposure, acidic and …

Multidrug efflux pumps: structure, function and regulation

D Du, X Wang-Kan, A Neuberger… - Nature Reviews …, 2018 - nature.com
Infections arising from multidrug-resistant pathogenic bacteria are spreading rapidly
throughout the world and threaten to become untreatable. The origins of resistance are …

Antidepressants can induce mutation and enhance persistence toward multiple antibiotics

Y Wang, Z Yu, P Ding, J Lu, L Mao… - Proceedings of the …, 2023 - National Acad Sciences
Antibiotic resistance is an urgent threat to global health. Antidepressants are consumed in
large quantities, with a similar pharmaceutical market share (4.8%) to antibiotics (5%). While …

Recovery of gut microbiota of healthy adults following antibiotic exposure

A Palleja, KH Mikkelsen, SK Forslund, A Kashani… - Nature …, 2018 - nature.com
To minimize the impact of antibiotics, gut microorganisms harbour and exchange antibiotics
resistance genes, collectively called their resistome. Using shotgun sequencing-based …

Persistent bacterial infections and persister cells

RA Fisher, B Gollan, S Helaine - Nature Reviews Microbiology, 2017 - nature.com
Many bacteria can infect and persist inside their hosts for long periods of time. This can be
due to immunosuppression of the host, immune evasion by the pathogen and/or ineffective …

Mechanisms of bacterial persistence during stress and antibiotic exposure

A Harms, E Maisonneuve, K Gerdes - Science, 2016 - science.org
BACKGROUND The escalating crisis of multidrug resistance is raising fears of untreatable
infections caused by bacterial “superbugs.” However, many patients already suffer from …

ATP-dependent dynamic protein aggregation regulates bacterial dormancy depth critical for antibiotic tolerance

Y Pu, Y Li, X Jin, T Tian, Q Ma, Z Zhao, S Lin, Z Chen… - Molecular cell, 2019 - cell.com
Cell dormancy is a widespread mechanism used by bacteria to evade environmental
threats, including antibiotics. Here we monitored bacterial antibiotic tolerance and regrowth …

Artificial sweeteners stimulate horizontal transfer of extracellular antibiotic resistance genes through natural transformation

Z Yu, Y Wang, IR Henderson, J Guo - The ISME Journal, 2022 - academic.oup.com
Antimicrobial resistance has emerged as a global threat to human health. Natural
transformation is an important pathway for horizontal gene transfer, which facilitates the …

Formation, physiology, ecology, evolution and clinical importance of bacterial persisters

B Van den Bergh, M Fauvart… - FEMS microbiology …, 2017 - academic.oup.com
Persisters are transiently tolerant variants that allow populations to avoid eradication by
antibiotic treatment. Their antibiotic tolerance is non-genetic, not inheritable and results from …

Acinetobacter baumannii Efflux Pumps and Antibiotic Resistance

SN Abdi, R Ghotaslou, K Ganbarov… - Infection and drug …, 2020 - Taylor & Francis
Acinetobacter baumannii is a nosocomial pathogen and gram-negative coccobacillus that is
responsible for opportunistic infections, pneumonia, and infections of the urinary tract …