Nano-based eye drop: Topical and noninvasive therapy for ocular diseases

C Wang, Y Pang - Advanced drug delivery reviews, 2023 - Elsevier
Eye drops are the most accessible therapy for ocular diseases, while inevitably suffering
from their lower bioavailability which highly restricts the treatment efficacy. The introduction …

Chitin and its derivatives: Structural properties and biomedical applications

SI Ahmad, R Ahmad, MS Khan, R Kant… - International Journal of …, 2020 - Elsevier
Chitin, a polysaccharide that occurs abundantly in nature after cellulose, has attracted the
interest of the scientific community due to its plenty of availability and low cost. Mostly, it is …

Alginate based polymeric systems for drug delivery, antibacterial/microbial, and wound dressing applications

V Hegde, UT Uthappa, T Altalhi, HY Jung… - Materials Today …, 2022 - Elsevier
Alginates are anionic, hydrophilic polysaccharides that are derived from brown seaweeds
and bacteria. The chemical structure contains β-D-mannuronic acid (M) and α-L-guluronic …

Developments in Emerging Topical Drug Delivery Systems for Ocular Disorders

S Mandal, P Vishvakarma… - Current Drug Research …, 2024 - benthamdirect.com
According to the current information, using nano gels in the eyes have therapeutic benefits.
Industry growth in the pharmaceutical and healthcare sectors has been filled by …

Chitosan and its derivatives for ocular delivery formulations: Recent advances and developments

A Zamboulis, S Nanaki, G Michailidou, I Koumentakou… - Polymers, 2020 - mdpi.com
Chitosan (CS) is a hemi-synthetic cationic linear polysaccharide produced by the
deacetylation of chitin. CS is non-toxic, highly biocompatible, and biodegradable, and it has …

Ocular drug delivery to the anterior segment using nanocarriers: A mucoadhesive/mucopenetrative perspective

RS Dave, TC Goostrey, M Ziolkowska… - Journal of Controlled …, 2021 - Elsevier
There is a growing demand for effective treatments for ocular conditions that improve patient
compliance and reduce side-effects. While methods such as implants and injections have …

Sustained release glaucoma therapies: Novel modalities for overcoming key treatment barriers associated with topical medications

A Belamkar, A Harris, R Zukerman, B Siesky… - Annals of …, 2022 - Taylor & Francis
Glaucoma is a progressive optic neuropathy and a leading cause of irreversible blindness.
The disease has conventionally been characterized by an elevated intraocular pressure …

Nanomedicine for the detection and treatment of ocular bacterial infections

X Huang, L Li, Z Chen, H Yu, X You, N Kong… - Advanced …, 2023 - Wiley Online Library
Ocular bacterial infection is a prevalent cause of blindness worldwide, with substantial
consequences for normal human life. Traditional treatments for ocular bacterial infections …

Breaking barriers in eye treatment: Polymeric nano-based drug-delivery system for anterior segment diseases and glaucoma

KY Wu, S Ashkar, S Jain, M Marchand, SD Tran - Polymers, 2023 - mdpi.com
The eye has anatomical structures that function as robust static and dynamic barriers,
limiting the penetration, residence time, and bioavailability of medications administered …

Clarithromycin-loaded ocular chitosan nanoparticle: formulation, optimization, characterization, ocular irritation, and antimicrobial activity

M Bin-Jumah, SJ Gilani, MA Jahangir… - International Journal …, 2020 - Taylor & Francis
Purpose The topically administered drugs through conventional delivery systems have low
bioavailability. Henceforth, the present study was designed to prepare and optimize …