Ciliopathies comprise a group of complex disorders, with involvement of the majority of
organs and systems. In total,> 180 causal genes have been identified and, in addition to …

Cholangiocarcinoma (CCA) is a highly invasive and metastatic form of carcinoma with bleak
prognosis due to limited therapies, frequent relapse, and chemotherapy resistance. There is …

Colorectal cancer (CRC) is one of the most common malignant tumors. Approximately 5%–
6% of CRC cases are associated with hereditary CRC syndromes, including the Peutz …

Activation of hepatic stellate cells (HSCs) plays a critical role in liver fibrosis. However, the
molecular basis for HSC activation remains poorly understood. Herein, we demonstrate that …

Purinergic receptors for extracellular nucleotides and nucleosides contribute to a vast array
of cellular and tissue functions, including cell proliferation, intracellular and transmembrane …

The primary cilium is an antennae‐like structure extent outside the cell surface. It has an
important role in regulating cell‐signaling transduction to affect proliferation, differentiation …

Endometrial decidualization plays a pivotal role during early pregnancy. Compromised
decidualization has been tightly associated with recurrent implantation failure (RIF). Primary …

Cilia are microtubule-based organelles that project from the cell surface with motility or
sensory functions. Primary cilia work as antennae to sense and transduce extracellular …

The primary cilium is an organelle that nearly all cells within the body contain. Its function is
to sense the extracellular environment through its abundance of receptors and linked …

Extracellular nucleotides are important intercellular signaling molecules that were found
enriched in the tumor microenvironment. In fact, interfering with G protein-coupled P2Y …