The histotripsy spectrum: differences and similarities in techniques and instrumentation

RP Williams, JC Simon, VA Khokhlova… - International Journal …, 2023 - Taylor & Francis
Since its inception about two decades ago, histotripsy–a non-thermal mechanical tissue
ablation technique–has evolved into a spectrum of methods, each with distinct potentiating …

[HTML][HTML] Research progress and clinical evaluation of histotripsy: a narrative review

S Li, Y Wei, B Zhang, X Li - Annals of Translational Medicine, 2023 - ncbi.nlm.nih.gov
Methods Literature published from January 2006 to March 2022 was retrieved from the
PubMed database. We reviewed these articles to examine histotripsy from the aspects of the …

Histology-based quantification of boiling histotripsy outcomes via ResNet-18 network: Towards mechanical dose metrics

E Ponomarchuk, G Thomas, M Song, A Krokhmal… - Ultrasonics, 2024 - Elsevier
This work was focused on the newly developed ultrasonic approach for non-invasive
surgery–boiling histotripsy (BH)–recently proposed for mechanical ablation of tissues using …

Mechanical damage thresholds for hematomas near gas-containing bodies in pulsed HIFU fields

EM Ponomarchuk, C Hunter, M Song… - Physics in Medicine …, 2022 - iopscience.iop.org
Objective. Boiling histotripsy (BH) is a novel high intensity focused ultrasound (HIFU)
application currently being developed for non-invasive mechanical fractionation of soft …

Elastic properties of aging human hematoma model in vitro and its susceptibility to histotripsy liquefaction

EM Ponomarchuk, PB Rosnitskiy, SA Tsysar… - Ultrasound in Medicine …, 2024 - Elsevier
Objective Tissue susceptibility to histotripsy disintegration has been reported to depend on
its elastic properties. This work was aimed at investigation of histotripsy efficiency for …

Boiling Histotripsy in Ex Vivo Human Brain: Proof-of-concept

E Ponomarchuk, S Tsysar, A Kadrev… - Ultrasound in Medicine …, 2024 - Elsevier
Objective Non-invasive surgical approaches, including boiling histotripsy (BH), are currently
being developed for the treatment of brain disorders aiming to avoid craniotomy and …

Pilot Study on Boiling Histotripsy Treatment of Human Leiomyoma Ex Vivo

E Ponomarchuk, S Tsysar, A Kvashennikova… - Ultrasound in Medicine …, 2024 - Elsevier
Objective As an alternative to surgical excision and magnetic resonance-guided thermal
high-intensity focused ultrasound ablation of uterine leiomyoma, this work was aimed at pilot …

Histotripsy of blood clots within a hollow cylindrical transducer for aspiration thrombectomy applications

L Gong, AR Wright, K Hynynen, DE Goertz - arXiv preprint arXiv …, 2024 - arxiv.org
Thrombolytic occlusions in stroke, pulmonary embolism and the peripheral vasculature are
increasingly treated with aspiration, a catheter-based approach that employs suction to …

Non-Thermal Liver Ablation: Existing and New Technology

T Nakla, JJ Chow, K Pham… - Seminars in …, 2023 - thieme-connect.com
Cancer has and continues to be a complex health crisis plaguing millions around the world.
Alcohol ablation was one of the initial methods used for the treatment of liver lesions. It was …

Pilot Experiment on Non-Invasive Non-Thermal Disintegration of Human Mucinous Breast Carcinoma Ex Vivo Using Boiling Histotripsy

EM Ponomarchuk, SA Tsysar, DD Chupova… - Bulletin of Experimental …, 2024 - Springer
We present the results of a pilot study demonstrating the feasibility of non-invasive non-
thermal disintegration of human mucinous carcinoma of the breast ex vivo using sequences …