Neuroprotective effect of SGLT2 inhibitors

A Pawlos, M Broncel, E Woźniak, P Gorzelak-Pabiś - Molecules, 2021 - mdpi.com
Patients with diabetes are at higher risk of cardiovascular diseases and cognitive
impairment. SGLT2 inhibitors (Empagliflozin, Canagliflozin, Dapagliflozin, Ertugliflozin …

Genomics of hypertension: the road to precision medicine

S Padmanabhan, AF Dominiczak - Nature Reviews Cardiology, 2021 - nature.com
The known genetic architecture of blood pressure now comprises> 30 genes, with rare
variants resulting in monogenic forms of hypertension or hypotension and> 1,477 common …

Obesity as a risk factor for Alzheimer's disease: weighing the evidence

S Alford, D Patel, N Perakakis, CS Mantzoros - Obesity reviews, 2018 - Wiley Online Library
Alzheimer's disease (AD) is the sixth leading cause of death in the USA today; therefore, it is
imperative that public health initiatives and clinical strategies are developed to prevent and …

Glucose transporters in brain: in health and in Alzheimer's disease

L Szablewski - Journal of Alzheimer's disease, 2017 - content.iospress.com
Neurons need a continuous supply of glucose, the major source of energy for mammalian
brain metabolism. The central nervous system is protected by three main physiological cell …

Diabetes drugs in the fight against Alzheimer's disease

V Boccardi, I Murasecco, P Mecocci - Ageing research reviews, 2019 - Elsevier
Alzheimer's disease (AD) is the most prevalent form of dementia, particularly in old age
subjects. Hyperinsulinemia and insulin resistance, which are known as pathophysiological …

Antidiabetic medication and risk of dementia in patients with type 2 diabetes: a nested case–control study

IK Wium-Andersen, M Osler… - European journal of …, 2019 - academic.oup.com
Objective Diabetes is a risk factor for dementia, but whether antidiabetic medication
decreases the risk is unclear. We examined the association between antidiabetic medication …

Newer glucose‐lowering drugs and risk of dementia: a systematic review and meta‐analysis of observational studies

H Tang, H Shao, CE Shaaban, K Yang… - Journal of the …, 2023 - Wiley Online Library
Background Preclinical studies have suggested potential beneficial effects of newer glucose‐
lowering drugs (GLDs) including dipeptidyl peptidase (DPP)‐4 inhibitors, glucagon‐like …

Perspective of SGLT2 inhibition in treatment of conditions connected to neuronal loss: focus on Alzheimer's disease and ischemia-related brain injury

M Wiciński, E Wódkiewicz, K Górski, M Walczak… - Pharmaceuticals, 2020 - mdpi.com
Sodium-glucose co-transporter 2 inhibitors (SGLT2i) are oral anti-hyperglycemic agents
approved for the treatment of type 2 diabetes mellitus. Some reports suggest their presence …

The association between sodium-glucose cotransporter 2 inhibitors and incident dementia: a nationwide population-based longitudinal cohort study

WZ Siao, TK Lin, JY Huang, CF Tsai… - … and Vascular Disease …, 2022 - journals.sagepub.com
Background The association of the use of sodium-glucose cotransporter 2 (SGLT2) inhibitor
and incident dementia remains unclear. This study aimed to evaluate the risk of incident …

The relationship between the blood-brain-barrier and the central effects of glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors

M Dong, S Wen, L Zhou - Diabetes, Metabolic Syndrome and …, 2022 - Taylor & Francis
Diabetes and obesity are growing problems worldwide and are associated with a range of
acute and chronic complications, including acute myocardial infarction (AMI) and stroke …