Mitochondria are best known for harboring pathways involved in ATP synthesis through the
tricarboxylic acid cycle and oxidative phosphorylation. Major advances in understanding …

Recent decades have seen a rapid increase in reported toxic effects of drugs and pollutants
on mitochondria. Researchers have also documented many genetic differences leading to …

Increasing evidence indicates that reactive oxygen species (ROS), consisting of superoxide,
hydrogen peroxide, and multiple others, do not only cause oxidative stress, but rather may …

The reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) protects
against redox stress by providing reducing equivalents to antioxidants such as glutathione …

Metabolism plays a significant role in the regulation of aging at different levels, and
metabolic reprogramming represents a major driving force in aging. Metabolic …

Mitochondria play numerous, essential roles in the life of eukaryotes. Disruption of
mitochondrial function in humans is often pathological or even lethal. Surprisingly, in some …

Mitochondria are essential for various biological processes including cellular energy
production. The oxidative stress theory of aging proposes that mitochondria play key roles in …

A mild reduction in mitochondrial respiration extends the life span of many species,
including C. elegans. We recently showed that hypoxia-inducible factor 1 (HIF-1) is required …

The genome of Caenorhabditis elegans encodes 284 nuclear hormone receptor, which
perform diverse functions in development and physiology. One of the best characterized of …

Mitochondrial dysfunction is considered as a critical mechanism in the pathogenesis of
Parkinson's disease (PD). Increasing evidence supports the notion of mitochondria …