This Review explores the class of plant-derived macrocyclic peptides called cyclotides. We
include an account of their discovery, characterization, and distribution in the plant kingdom …

Eusocial insects exemplify a remarkable system of division of labor within the same colony.
This behavioral range, which is sometimes accompanied by morphological or physiological …

Cyclotides are a novel class of micro-proteins (≈ 30–40 residues long) with a unique
topology containing a head-to-tail cyclized backbone structure further stabilized by three …

G protein-coupled receptors (GPCRs) represent important drug targets, as they regulate
pivotal physiological processes and they have proved to be readily druggable. Natural …

Cyclotides are plant-derived cyclic, disulfide-rich peptides with a unique cyclic cystine knot
topology that confers them with remarkable structural stability and resistance to proteolytic …

Highlights•Cyclotides are short disulfide rich peptides isolated from several plant
families.•Cyclotides have a head to tail cyclized backbone structure.•The structure of …

Cyclotides are plant-derived disulfide-rich peptides comprising a cyclic cystine knot, which
confers remarkable stability against thermal, proteolytic, and chemical degradation. They …

Abstract The cholecystokinin-2 receptor (CCK2R) is a G protein-coupled receptor (GPCR)
that is expressed in peripheral tissues and the central nervous system and constitutes a …

Cyclotides are an extremely stable class of peptides, ubiquitously distributed in Violaceae.
The aim of the present study was to investigate the presence of cyclotides in Sri Lankan …

Mosquito breeding depends on the supply of fresh vertebrate blood, a major bottleneck for
large-scale production of Anopheles spp. Feeding alternatives to fresh blood are thus a …