Cocrystals of apixaban with improved solubility and permeability: formulation, physicochemical characterization, pharmacokinetic evaluation, and computational …
JR Madan, SV Waghmare, RB Patil… - Assay and drug …, 2021 - liebertpub.com
The objective of the current study was to develop new cocrystals of Apixaban (APX) to
improve its solubility and permeability. The molecular interaction between APX and caffeine …
improve its solubility and permeability. The molecular interaction between APX and caffeine …
Apixaban (I) in several aqueous co-solvent mixtures: Solubility, solvent effect and preferential solvation
H Li, A Farajtabar, Y Xie, Z Li, H Zhao - The Journal of Chemical …, 2020 - Elsevier
Equilibrium apixaban (I) solubility in isopropanol (1)+ water (2), ethanol (1)+ water (2),
acetone (1)+ water (2) and methanol (1)+ water (2) mixtures was acquired by a shake-flask …
acetone (1)+ water (2) and methanol (1)+ water (2) mixtures was acquired by a shake-flask …
Dissolution behavior and thermodynamic properties of apixaban in pure and mixed solvents
C Du, Y Cong, Y Zhang, Y Xue, B Qiao, T Ye… - The Journal of Chemical …, 2020 - Elsevier
The solubility profile of apixaban in pure and mixed solvents within the temperature range
from (288.15 to 328.15) K under atmosphere pressure (101.3 kPa) was studied and …
from (288.15 to 328.15) K under atmosphere pressure (101.3 kPa) was studied and …