The steep rise of type 2 diabetes mellitus (T2DM) and associated complications go along
with mounting evidence of clinically important sex and gender differences. T2DM is more …

Parkinson's disease (PD) displays a greater prevalence and earlier age at onset in men.
This review addresses the concept that sex differences in PD are determined, largely, by …

The methylome is subject to genetic and environmental effects. Their impact may depend on
sex and age, resulting in sex-and age-related physiological variation and disease …

Background & Aims Although the incidence of inflammatory bowel diseases (IBDs) varies
with age, few studies have examined variations between the sexes. We therefore used …

The global pandemic of obesity and type 2 diabetes is often causally linked to marked
changes in diet and lifestyle; namely marked increases in dietary intakes of high energy …

The gender difference in cancer susceptibility is one of the most consistent findings in
cancer epidemiology. Hematologic malignancies are generally more common in males and …

Dopamine is involved in drug reinforcement but its role in addiction is less clear. Here we
describe PET imaging studies that investigate dopamine's involvement in drug abuse in the …

Major efforts have been directed at family-based association and case–control studies to
identify the involvement of candidate genes in the major disorders of mental health. What …

The epigenome has been heralded as a key'missing piece'of the aetiological puzzle for
complex phenotypes across the biomedical sciences. The standard research approaches …

Epigenetic misregulation is consistent with various non-Mendelian features of schizophrenia
and bipolar disorder. To date, however, few studies have investigated the role of DNA …