Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

H Sies, VV Belousov, NS Chandel, MJ Davies… - … reviews Molecular cell …, 2022 - nature.com
Abstract 'Reactive oxygen species'(ROS) is a generic term that defines a wide variety of
oxidant molecules with vastly different properties and biological functions that range from …

RONS and oxidative stress: An overview of basic concepts

AK Aranda-Rivera, A Cruz-Gregorio… - Oxygen, 2022 - mdpi.com
Oxidative stress (OS) has greatly interested the research community in understanding
damaging processes occurring in cells. OS is triggered by an imbalance between reactive …

[HTML][HTML] Generation of reactive oxygen species by mitochondria

P Hernansanz-Agustín, JA Enríquez - Antioxidants, 2021 - mdpi.com
Reactive oxygen species (ROS) are series of chemical products originated from one or
several electron reductions of oxygen. ROS are involved in physiology and disease and can …

Oxidative stress in non-alcoholic fatty liver disease. An updated mini review

AP Delli Bovi, F Marciano, C Mandato, MA Siano… - Frontiers in …, 2021 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is a challenging disease caused by multiple
factors, which may partly explain why it remains still orphan of an adequate therapeutic …

Structural and functional properties of food protein‐derived antioxidant peptides

ID Nwachukwu, RE Aluko - Journal of food biochemistry, 2019 - Wiley Online Library
The aim of this work is to provide a timely examination of the structure–activity relationship of
antioxidative peptides. The main production approach involves enzymatic hydrolysis of …

Production of superoxide and hydrogen peroxide from specific mitochondrial sites under different bioenergetic conditions

HS Wong, PA Dighe, V Mezera, PA Monternier… - Journal of Biological …, 2017 - ASBMB
Mitochondrial production of superoxide and hydrogen peroxide is potentially important in
cell signaling and disease. Eleven distinct mitochondrial sites that differ markedly in capacity …

[HTML][HTML] Metabolic zonation of the liver: The oxygen gradient revisited

T Kietzmann - Redox biology, 2017 - Elsevier
The liver has a multitude of functions which are necessary to maintain whole body
homeostasis. This requires that various metabolic pathways can run in parallel in the most …

Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells

S Ma, ES Henson, Y Chen, SB Gibson - Cell death & disease, 2016 - nature.com
Ferroptosis is an iron-dependent, oxidative cell death, and is distinct from apoptosis,
necrosis and autophagy. In this study, we demonstrated that lysosome disrupting agent …

Oxidative stress and cellular response to doxorubicin: a common factor in the complex milieu of anthracycline cardiotoxicity

D Cappetta, A De Angelis, L Sapio… - Oxidative medicine …, 2017 - Wiley Online Library
The production of reactive species is a core of the redox cycling profile of anthracyclines.
However, these molecular characteristics can be viewed as a double‐edged sword acting …

The involvement of the oxidative stress status in cancer pathology: a double view on the role of the antioxidants

KF Zahra, R Lefter, A Ali, EC Abdellah… - Oxidative Medicine …, 2021 - Wiley Online Library
Oxygen‐free radicals, reactive oxygen species (ROS) or reactive nitrogen species (RNS),
are known by their “double‐sided” nature in biological systems. The beneficial effects of …