[HTML][HTML] The role of IGRA in the diagnosis of tuberculosis infection, differentiating from active tuberculosis, and decision making for initiating treatment or preventive …
ABSTRACT Objectives The World Health Organization estimated that a quarter of the global
population is infected by Mycobacterium tuberculosis (Mtb). A better control of tuberculosis …
population is infected by Mycobacterium tuberculosis (Mtb). A better control of tuberculosis …
A Systematic Review on Novel Mycobacterium tuberculosis Antigens and Their Discriminatory Potential for the Diagnosis of Latent and Active Tuberculosis
NR Meier, M Jacobsen, THM Ottenhoff… - Frontiers in …, 2018 - frontiersin.org
Background: Current immunodiagnostic tests for tuberculosis (TB) are based on the
detection of an immune response toward mycobacterial antigens injected into the skin or …
detection of an immune response toward mycobacterial antigens injected into the skin or …
[HTML][HTML] A whole blood test to measure SARS-CoV-2-specific response in COVID-19 patients
Objectives To examine whether specific T-cell-responses to SARS-CoV-2 peptides can be
detected in COVID-19 using a whole-blood experimental setting, which may be further …
detected in COVID-19 using a whole-blood experimental setting, which may be further …
Identification of antigens presented by MHC for vaccines against tuberculosis
Mycobacterium tuberculosis (M. tb) is responsible for more deaths globally than any other
pathogen. The only available vaccine, bacillus Calmette-Guérin (BCG), has variable efficacy …
pathogen. The only available vaccine, bacillus Calmette-Guérin (BCG), has variable efficacy …
Preventive therapy for tuberculosis in rheumatological patients undergoing therapy with biological drugs
D Goletti, L Petrone, G Ippolito, L Niccoli… - Expert Review of Anti …, 2018 - Taylor & Francis
Introduction: Latent tuberculosis infection (LTBI) accounts for almost a quarter of the world
population, and, in 5–10% of the subjects with impaired immune-response against M …
population, and, in 5–10% of the subjects with impaired immune-response against M …
Multi-country evaluation of RISK6, a 6-gene blood transcriptomic signature, for tuberculosis diagnosis and treatment monitoring
R Bayaa, MDB Ndiaye, C Chedid, E Kokhreidze… - Scientific Reports, 2021 - nature.com
There is a crucial need for non-sputum-based TB tests. Here, we evaluate the performance
of RISK6, a human-blood transcriptomic signature, for TB screening, triage and treatment …
of RISK6, a human-blood transcriptomic signature, for TB screening, triage and treatment …
Combined use of Quantiferon and HBHA-based IGRA supports tuberculosis diagnosis and therapy management in children
Objectives Interferon-γ release assays (IGRA) are designed for diagnosis of tuberculosis
(TB) infection, and do not discriminate latent TB infection (LTBI) from active TB. Heparin …
(TB) infection, and do not discriminate latent TB infection (LTBI) from active TB. Heparin …
Mycobacterial heparin-binding hemagglutinin (HBHA)-induced interferon-γ release assay (IGRA) for discrimination of latent and active tuberculosis: A systematic …
J Tang, Y Huang, Z Cai, Y Ma - PLoS One, 2021 - journals.plos.org
Background The Mycobacterial heparin-binding hemagglutinin (HBHA) is an important
latency-associated antigen that can be used to distinguish between latent tuberculosis …
latency-associated antigen that can be used to distinguish between latent tuberculosis …
Effect of therapy on Quantiferon-Plus response in patients with active and latent tuberculosis infection
Lack of biomarkers for treatment monitoring is listed among the main requirements for next
generation assays, as identified globally among tuberculosis (TB) researchers. In this study …
generation assays, as identified globally among tuberculosis (TB) researchers. In this study …
[HTML][HTML] Impact of antiretroviral and tuberculosis therapies on CD4+ and CD8+ HIV/M. tuberculosis-specific T-cell in co-infected subjects
Abstract Background Human Immunodeficiency Virus (HIV) infection is a risk factor for
tuberculosis (TB). Antiretroviral therapy (ART) changed HIV clinical management but it is still …
tuberculosis (TB). Antiretroviral therapy (ART) changed HIV clinical management but it is still …