Protein kinases regulate nearly all aspects of cell life, and alterations in their expression, or
mutations in their genes, cause cancer and other diseases. Here, we review the remarkable …

The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …

An enhanced understanding of the importance of Janus kinase (JAK) and signal transducer
and activator of transcription (STAT) signalling in multiple disease states has led to an …

Cytokines are secreted or membrane-presented molecules that mediate broad cellular
functions, including development, differentiation, growth and survival. Accordingly, the …

Abstract The IL-6/JAK/STAT3 pathway is aberrantly hyperactivated in many types of cancer,
and such hyperactivation is generally associated with a poor clinical prognosis. In the …

Cytokines signal through cell surface receptor dimers to initiate activation of intracellular
Janus kinases (JAKs). We report the 3.6-angstrom–resolution cryo–electron microscopy …

The new edition of the 2016 World Health Organization (WHO) classification system for
tumors of the hematopoietic and lymphoid tissues was published in September 2017. Under …

Abstract Interleukin-6 (IL-6) is a pivotal cytokine with a diverse repertoire of physiological
functions that include regulation of immune cell proliferation and differentiation …

Abstract Kinases of the Jak ('Janus kinase') family and transcription factors (TFs) of the STAT
('signal transducer and activator of transcription') family constitute a rapid membrane-to …

Janus tyrosine kinase (JAK) family of proteins have been identified as crucial proteins in
signal transduction initiated by a wide range of membrane receptors. Among the proteins in …