Adaptation is one of physiology's fundamental tenets, operating not only at the level of
species, as Darwin proposed, but also at the level of tissues, cells, molecules and, perhaps …

NMDA (N-methyl-d-aspartate) receptors are a subtype of ionotropic glutamate receptor with
an important role in the physiology and pathophysiology of central neurons. Inappropriate …

Cerebral ischemia is one of the leading causes of morbidity and mortality worldwide.
Although stroke (a form of cerebral ischemia)-related costs are expected to reach 240.67 …

Depression and cognitive disorders are diseases with complex and not-fully understood
etiology. Unfortunately, the COVID-19 pandemic dramatically increased the prevalence of …

Recent studies in a variety of species including mammals showed that resveratrol (trans-3,
5, 4 ″-trihydroxystibene) treatment and caloric restriction increased silent information …

Neuroprotection can be induced by low doses of NMDA, which activate both synaptic and
extrasynaptic NMDA receptors. This is in apparent contradiction with our recent findings that …

Background and Purpose—Stroke is a leading cause of disability and death in the United
States, yet limited therapeutic options exist. The need for novel neuroprotective agents has …

In the area of brain injury and neurodegenerative diseases, a plethora of experimental and
clinical evidence strongly indicates the promise of therapeutically exploiting the endogenous …

Brain ischemia is one of the most common causes of death and the leading cause of adult
disability in the world. Brain ischemic preconditioning (BIP) refers to a transient, sublethal …

Protein kinase C (PKC) has been implicated in mediating ischemic and reperfusion damage
in multiple organs. However, conflicting reports exist on the role of individual PKC isozymes …