The gut microbiome associates with immune checkpoint inhibition outcomes in patients with advanced non–small cell lung cancer
T Hakozaki, C Richard, A Elkrief, Y Hosomi… - Cancer Immunology …, 2020 - AACR
The gut microbiome (GM) plays an important role in shaping systemic immune responses
and influences immune checkpoint inhibitor (ICI) efficacy. Antibiotics worsen clinical …
and influences immune checkpoint inhibitor (ICI) efficacy. Antibiotics worsen clinical …
Targeting the gut microbiome to mitigate immunotherapy-induced colitis in cancer
Immune checkpoint inhibitors (ICIs) have been a transformational advance in cancer therapy
in the past decade. However, ICIs can produce immune-related adverse effects (irAEs) …
in the past decade. However, ICIs can produce immune-related adverse effects (irAEs) …
Gut microbial signature in lung cancer patients highlights specific taxa as predictors for durable clinical benefit
Y Haberman, I Kamer, A Amir, S Goldenberg… - Scientific Reports, 2023 - nature.com
We aimed to determine microbial signature linked with lung cancer (LC) diagnosis and to
define taxa linked with durable clinical benefit (DCB) of advanced LC patients. Stool …
define taxa linked with durable clinical benefit (DCB) of advanced LC patients. Stool …
Mining the gut microbiota for microbial-based therapeutic strategies in cancer immunotherapy
B Li, T Gong, Y Hao, X Zhou, L Cheng - Frontiers in Oncology, 2021 - frontiersin.org
The past two decades witnessed a revolution in our understanding of host–microbiota
interactions that led to the concept of the super-organism consisting of a eukaryotic part and …
interactions that led to the concept of the super-organism consisting of a eukaryotic part and …
Fecal microbiota transplantation as a mean of overcoming immunotherapy-resistant cancers–hype or hope?
EN Baruch, T Gaglani… - Therapeutic Advances in …, 2021 - journals.sagepub.com
NCT03819296). These findings suggest that the combination of FMT and ICI is not only a
more effective treatment but may also have a better safety profile. This potential duality of a …
more effective treatment but may also have a better safety profile. This potential duality of a …
Gut microbes as medical signature for the effectiveness of immunotherapy in patients with advanced non‐small cell lung cancer
A Adugna, Y Muche, M Jemal, SD Habtegiorgis… - Aging …, 2024 - Wiley Online Library
Lung cancer (LC) is the most common cause of cancer‐related death worldwide and poses
a severe threat to public health. Immunotherapy with checkpoint blockers has improved the …
a severe threat to public health. Immunotherapy with checkpoint blockers has improved the …
Munching microbes: diet–microbiome interactions shape gut health and cancer outcomes
E Todd, R Elnour, R Simpson, M Castaneda… - Microbiology …, 2021 - CSIRO Publishing
The gut microbiome describes the complex community of microorganisms that populate the
gastrointestinal tract. Gut microbes in the large bowel utilise both dietary-derived nutrients …
gastrointestinal tract. Gut microbes in the large bowel utilise both dietary-derived nutrients …