Although nerve cell death is the hallmark of many neurological diseases, the processes
underlying this death are still poorly defined. However, there is a general consensus that …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that results
in the loss of motor function in the central nervous system (CNS) and ultimately death. The …

Pluripotent stem cells hold great promise in regenerative medicine and developmental
biology studies. Mitochondrial metabolites, including tricarboxylic acid (TCA) cycle …

GADD45 is a gene family consisting of GADD45A, GADD45B, and GADD45G that is often
induced by DNA damage and other stress signals associated with growth arrest and …

Identifying molecular and cellular processes that regulate reprogramming competence of
transcription factors broadens our understanding of reprogramming mechanisms. In the …

Here we develop a methylation editing toolbox, Casilio-ME, that enables not only RNA-
guided methylcytosine editing by targeting TET1 to genomic sites, but also by co-delivering …

OCT4 (also known as POU5F1) plays an essential role in reprogramming. It is the only
member of the POU (Pit-Oct-Unc) family of transcription factors that can induce pluripotency …

There has been a renewed interest in the identification of natural products having premium
pharmacological properties and minimum off-target effects. In accordance with this …

Reprogramming of somatic cells to induced pluripotent stem cells reconfigures chromatin
modifications. Whether and how this process is regulated by signals originating in the …

The pluripotency of stem cells determines their developmental potential. While the
pluripotency states of pluripotent stem cells are variable and interconvertible, the …