Rheumatoid arthritis—common origins, divergent mechanisms

EM Gravallese, GS Firestein - New England Journal of Medicine, 2023 - Mass Medical Soc
Rheumatoid Arthritis — Common Origins, Divergent Mechanisms | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies

Q Guo, Y Wang, D Xu, J Nossent, NJ Pavlos, J Xu - Bone research, 2018 - nature.com
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that primarily affects
the lining of the synovial joints and is associated with progressive disability, premature …

Rheumatoid arthritis pathogenesis, prediction, and prevention: an emerging paradigm shift

KD Deane, VM Holers - Arthritis & Rheumatology, 2021 - Wiley Online Library
Rheumatoid arthritis (RA) is currently diagnosed and treated when an individual presents
with signs and symptoms of inflammatory arthritis (IA) as well as other features, such as …

Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction

VM Holers, MK Demoruelle, KA Kuhn… - Nature Reviews …, 2018 - nature.com
Individuals at high risk of developing seropositive rheumatoid arthritis (RA) can be identified
for translational research and disease prevention studies through the presence of highly …

The pre-clinical phase of rheumatoid arthritis: from risk factors to prevention of arthritis

N Petrovská, K Prajzlerová, J Vencovský, L Šenolt… - Autoimmunity …, 2021 - Elsevier
Rheumatoid arthritis (RA) is a chronic autoimmune disease considered as a multistep
process spanning from the interaction of genetic (eg, shared epitope or non-HLA loci) …

Preclinical autoimmune disease: a comparison of rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis and type 1 diabetes

G Frazzei, RF van Vollenhoven, BA de Jong… - Frontiers in …, 2022 - frontiersin.org
The preclinical phase of autoimmune disorders is characterized by an initial asymptomatic
phase of varying length followed by nonspecific signs and symptoms. A variety of …

Lactobacillus casei CCFM1074 Alleviates Collagen-Induced Arthritis in Rats via Balancing Treg/Th17 and Modulating the Metabolites and Gut Microbiota

Z Fan, RP Ross, C Stanton, B Hou, J Zhao… - Frontiers in …, 2021 - frontiersin.org
Gut microbiota and their influence on metabolites are receiving increasing attentions in
autoimmune diseases including rheumatoid arthritis (RA). Probiotics become a promising …

The natural history of rheumatoid arthritis

KD Deane, VM Holers - Clinical therapeutics, 2019 - Elsevier
Purpose This article reviews the phases of rheumatoid arthritis (RA) development in terms of
the evolution of disease, with a focus on events that occur before the first appearance of …

Preclinical rheumatoid arthritis and rheumatoid arthritis prevention

HK Greenblatt, HA Kim, LF Bettner… - Current opinion in …, 2020 - journals.lww.com
The results from ongoing natural history and prevention trials in RA should further inform
several critical issues in RA prevention including identification and enrolment of individuals …

Potential of lifestyle changes for reducing the risk of developing rheumatoid arthritis: is an ounce of prevention worth a pound of cure?

A Zaccardelli, HM Friedlander, JA Ford, JA Sparks - Clinical therapeutics, 2019 - Elsevier
Purpose Lifestyle may be important in the development of rheumatoid arthritis (RA).
Therefore, changing behaviors may delay or even prevent RA onset. This article reviews the …