Neurotrophic factors, particularly BDNF (brain-derived neurotrophic factor), have been
associated with depression and antidepressant drug action. A variety of preclinical and …

Hippocampal volume increase in response to aerobic exercise has been consistently
observed in animal models. However, the evidence from human studies is equivocal. We …

Abstract The 'Executive Functions'(EFs) of inhibitory control, working memory, and cognitive
flexibility enable us to think before we act, resist temptations or impulsive reactions, stay …

Exercise can improve clinical outcomes in people with severe mental illness (SMI).
However, this population typically engages in low levels of physical activity with poor …

Cognitive deficits are pervasive among people with schizophrenia and treatment options are
limited. There has been an increased interest in the neurocognitive benefits of exercise, but …

Physically-active video games ('exergames') have recently gained popularity for leisure and
entertainment purposes. Using exergames to combine physical activity and cognitively …

We performed a meta-analysis to synthesize evidence on the efficacy and safety of physical
exercise as an add-on therapeutic intervention for quality of life (QoL), depressive symptoms …

Background: Physical exercise may be valuable for patients with schizophrenia spectrum
disorders as it may have beneficial effect on clinical symptoms, quality of life and cognition …

Levels of brain-derived neurotrophic factor (BDNF) are reduced in the brain and serum of
depressed patients and at least the reduction in serum levels is reversible upon successful …

Background Cardiorespiratory fitness (CRF) among people with severe mental illness
(SMI)(ie, schizophrenia, bipolar disorder, and major depressive disorder) is a critical clinical …