Copper is an essential micronutrient involved in fundamental life processes that are
conserved throughout all forms of life. The ability of copper to catalyze oxidation–reduction …

Copper is an important trace element that is required for essential enzymes. However, due
to its redox activity, copper can also lead to the generation of toxic reactive oxygen species …

Copper is a trace element, important for the function of many cellular enzymes. Copper ions
can adopt distinct redox states oxidized Cu (II) or reduced (I), allowing the metal to play a …

Copper-transporting ATPases (Cu-ATPases) ATP7A and ATP7B are evolutionarily
conserved polytopic membrane proteins with essential roles in human physiology. The Cu …

Hepatocytes, like other epithelia, are situated at the interface between the organism's
exterior and the underlying internal milieu and organize the vectorial exchange of …

The cellular uptake and intracellular distribution of the essential but highly toxic nutrient,
copper, is a precisely orchestrated process. Copper homeostasis is coordinated by several …

Interactions between the essential dietary metals, iron and copper, have been known for
many years. This review highlights recent advances in iron-copper interactions with a focus …

Copper (Cu) and its alloys are used extensively in domestic and industrial applications. Cu
is also an essential element in mammalian nutrition. Since both copper deficiency and …

Copper is essential for human health and copper imbalance is a key factor in the aetiology
and pathology of several neurodegenerative diseases. The copper-transporting P-type …

The aim of this review is to give a general view on the current status of the scientific basis for
the role of copper in human health and disease, outlining the roles of copper in human …