Mitochondrial dysfunction: A cellular and molecular hub in pathology of metabolic diseases and infection
Mitochondria are semiautonomous doubly membraned intracellular components of cells.
The organelle comprises of an external membrane, followed by coiled structures within the …
The organelle comprises of an external membrane, followed by coiled structures within the …
[HTML][HTML] Mitochondrial motility modulators coordinate quality control dynamics to promote neuronal health
JE Jenkins, M Fazli, CS Evans - Current Opinion in Cell Biology, 2024 - Elsevier
Dysfunction in mitochondrial maintenance and trafficking is commonly correlated with the
development of neurodegenerative disorders such as Parkinson's disease and Alzheimer's …
development of neurodegenerative disorders such as Parkinson's disease and Alzheimer's …
[HTML][HTML] In an experimental myocardial infarction model, L-arginine pre-intervention may exert cardioprotective effects by regulating OTULIN levels and mitochondrial …
The experimental myocardial infarction (MI) model originating from isoproterenol (ISO) is
frequently preferred in research due to its similarity to MI-induced damage in humans …
frequently preferred in research due to its similarity to MI-induced damage in humans …
DNA methylation-mediated Mfn2 gene regulation in the brain: a role in brain trauma-induced mitochondrial dysfunction and memory deficits
PG Kulkarni, N Balasubramanian, R Manjrekar… - Cellular and Molecular …, 2023 - Springer
Repeated mild traumatic brain injuries (rMTBI) affect mitochondrial homeostasis in the brain.
However, mechanisms of long-lasting neurobehavioral effects of rMTBI are largely unknown …
However, mechanisms of long-lasting neurobehavioral effects of rMTBI are largely unknown …
Metformin normalizes mitochondrial function to delay astrocyte senescence in a mouse model of Parkinson's disease through Mfn2-cGAS signaling
M Wang, T Tian, H Zhou, SY Jiang, YY Jiao… - Journal of …, 2024 - Springer
Background Senescent astrocytes play crucial roles in age-associated neurodegenerative
diseases, including Parkinson's disease (PD). Metformin, a drug widely used for treating …
diseases, including Parkinson's disease (PD). Metformin, a drug widely used for treating …
[HTML][HTML] ER-organelle contacts: A signaling hub for neurological diseases
Y Wang, J Yang - Pharmacological Research, 2024 - Elsevier
Neuronal health is closely linked to the homeostasis of intracellular organelles, and
organelle dysfunction affects the pathological progression of neurological diseases. In …
organelle dysfunction affects the pathological progression of neurological diseases. In …
Interplay of mitochondria associated membrane proteins and autophagy: Implications in neurodegeneration
PG Kulkarni, VM Mohire, PP Waghmare, T Banerjee - Mitochondrion, 2024 - Elsevier
Since the discovery of membrane contact sites between ER and mitochondria called
mitochondria-associated membranes (MAMs), several pieces of evidence identified their …
mitochondria-associated membranes (MAMs), several pieces of evidence identified their …
Mfn2 regulates mitochondria and mitochondria-associated endoplasmic reticulum membrane function in neurodegeneration induced by repeated sevoflurane …
R Zhu, L Liu, T Mao, X Wang, Y Li, T Li, S Lv… - Experimental …, 2024 - Elsevier
Repeated sevoflurane exposure in neonatal mice can leads to neuronal apoptosis and
mitochondrial dysfunction. The mitochondria are responsible for energy production to …
mitochondrial dysfunction. The mitochondria are responsible for energy production to …