The physiological roles of tau and Aβ: implications for Alzheimer's disease pathology and therapeutics

SA Kent, TL Spires-Jones, CS Durrant - Acta neuropathologica, 2020 - Springer
Tau and amyloid beta (Aβ) are the prime suspects for driving pathology in Alzheimer's
disease (AD) and, as such, have become the focus of therapeutic development. Recent …

Geriatric traumatic brain injury: epidemiology, outcomes, knowledge gaps, and future directions

RC Gardner, K Dams-O'Connor… - Journal of …, 2018 - liebertpub.com
This review of the literature on traumatic brain injury (TBI) in older adults focuses on incident
TBI sustained in older adulthood (“geriatric TBI”) rather than on the separate, but related …

The international incidence of traumatic brain injury: a systematic review and meta-analysis

R Nguyen, KM Fiest, J McChesney… - Canadian journal of …, 2016 - cambridge.org
Background: Understanding the epidemiology of traumatic brain injury (TBI) is essential to
shape public health policy, implement prevention strategies, and justify allocation of …

[HTML][HTML] Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis

AC Bolte, AB Dutta, ME Hurt, I Smirnov… - Nature …, 2020 - nature.com
Traumatic brain injury (TBI) is a leading global cause of death and disability. Here we
demonstrate in an experimental mouse model of TBI that mild forms of brain trauma cause …

Severe traumatic brain injury: targeted management in the intensive care unit

N Stocchetti, M Carbonara, G Citerio, A Ercole… - The Lancet …, 2017 - thelancet.com
Severe traumatic brain injury (TBI) is currently managed in the intensive care unit with a
combined medical–surgical approach. Treatment aims to prevent additional brain damage …

Epidemiology of traumatic brain injury

M Faul, V Coronado - Handbook of clinical neurology, 2015 - Elsevier
Traumatic brain injury (TBI) is a leading cause of death, and in a recent analysis it was found
that nearly one-third of all injury-related deaths in the US have at least one diagnosis of TBI …

Animal models of traumatic brain injury

Y Xiong, A Mahmood, M Chopp - Nature Reviews Neuroscience, 2013 - nature.com
Traumatic brain injury (TBI) is a leading cause of mortality and morbidity both in civilian life
and on the battlefield worldwide. Survivors of TBI frequently experience long-term disabling …

Mitochondrial function in hypoxic ischemic injury and influence of aging

PB Ham III, R Raju - Progress in neurobiology, 2017 - Elsevier
Mitochondria are a major target in hypoxic/ischemic injury. Mitochondrial impairment
increases with age leading to dysregulation of molecular pathways linked to mitochondria …

Aging of cerebral white matter

H Liu, Y Yang, Y Xia, W Zhu, RK Leak, Z Wei… - Ageing research …, 2017 - Elsevier
White matter (WM) occupies a large volume of the human cerebrum and is mainly composed
of myelinated axons and myelin-producing glial cells. The myelinated axons within WM are …

Traumatic intracranial hypertension

N Stocchetti, AIR Maas - New England Journal of Medicine, 2014 - Mass Medical Soc
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