The nonsense-mediated mRNA decay (NMD) pathway degrades some but not all mRNAs
bearing premature termination codons (PTCs). Decades of work have elucidated the …

Nonsense-mediated mRNA decay (NMD) is probably the best characterized eukaryotic RNA
degradation pathway. Through intricate steps, a set of NMD factors recognize and degrade …

Upstream open reading frames (uORFs) are major gene expression regulatory elements. In
many eukaryotic mRNAs, one or more uORFs precede the initiation codon of the main …

Nonsense-mediated mRNA decay (NMD) is a translation-coupled mechanism that
eliminates mRNAs containing premature translation-termination codons (PTCs). In …

Nonsense mutations account for∼ 11% of all described gene lesions causing human
inherited disease and∼ 20% of disease‐associated single‐basepair substitutions affecting …

Nonsense-mediated mRNA decay (NMD) is a quality control pathway in eukaryotes that
continuously monitors mRNA transcripts to ensure truncated polypeptides are not produced …

Nonsense-mediated decay is well known by the lucid definition of being a RNA surveillance
mechanism that ensures the speedy degradation of mRNAs containing premature …

Nonsense‐mediated RNA decay (NMD) is an evolutionarily conserved RNA quality control
process that serves both as a mechanism to eliminate aberrant transcripts carrying …

Nonsense-mediated mRNA decay (NMD) generally involves nonsense codon recognition
by translating ribosomes at a position∼ 25 nts upstream of a splicing-generated exon …

Nonsense-mediated mRNA decay (NMD) is a conserved translation-coupled quality control
mechanism in all eukaryotes that regulates the expression of a significant fraction of both the …