Differential Role of Factor XIII in Acute Myocardial Infarction and Ischemic Stroke

J Traub, MS Weber, A Frey - Biomedicines, 2024 - mdpi.com
Factor XIII is a transglutaminase enzyme that plays a crucial role in hemostasis and wound
healing. It crosslinks fibrin strands, stabilizing clots and promoting clot resistance to …

Coagulation factor XIII variants with altered thrombin activation rates

MD Andersen, M Kjalke, S Bang, I Lautrup-Larsen… - 2009 - degruyter.com
Coagulation factor XIII (FXIII) is activated by thrombin and catalyses crosslinking between
fibrin monomers thereby providing mechanical strength to the fibrin network. V34L is a …

In silico studies of blood coagulation proteins: from mosaic proteases to nonenzymatic cofactor inhibitors

BO Villoutreix, O Sperandio - Current opinion in structural biology, 2010 - Elsevier
Blood coagulation disorders are leading causes of death worldwide. The system involves
over 20 proteins that interact specifically with various degrees of affinity on appropriate cell …

Structure and behavior of human α-Thrombin upon ligand recognition: thermodynamic and molecular dynamics studies

VA Silva, MT Cargnelutti, GM Giesel, LC Palmieri… - PLoS …, 2011 - journals.plos.org
Thrombin is a serine proteinase that plays a fundamental role in coagulation. In this study,
we address the effects of ligand site recognition by alpha-thrombin on conformation and …

Design of Factor XIII V34X activation peptides to control ability to interact with thrombin mutants

MA Jadhav, RC Lucas, WN Goldsberry… - Biochimica et Biophysica …, 2011 - Elsevier
Thrombin helps to activate Factor XIII (FXIII) by hydrolyzing the R37-G38 peptide bond. The
resultant transglutaminase introduces cross-links into the fibrin clot. With the development of …

Effects of introducing fibrinogen Aα character into the factor XIII activation peptide segment

MA Jadhav, G Isetti, TA Trumbo, MC Maurer - Biochemistry, 2010 - ACS Publications
The formation of a blood clot involves the interplay of thrombin, fibrinogen, and Factor XIII.
Thrombin cleaves fibrinopeptides A and B from the N-termini of the fibrinogen Aα and Bβ …