Adapting to survive: How Candida overcomes host-imposed constraints during human colonization

R Alves, C Barata-Antunes, M Casal, AJP Brown… - PLoS …, 2020 - journals.plos.org
Successful human colonizers such as Candida pathogens have evolved distinct strategies
to survive and proliferate within the human host. These include sophisticated mechanisms to …

Mechanisms of Porphyromonas gingivalis to translocate over the oral mucosa and other tissue barriers

CA de Jongh, TJ de Vries, FJ Bikker… - Journal of Oral …, 2023 - Taylor & Francis
ABSTRACT Introduction The oral pathogen Porphyromonas gingivalis is not only associated
with periodontitis but also with systemic diseases elsewhere in the body. The mechanisms …

Mitochondrial proline catabolism activates Ras1/cAMP/PKA-induced filamentation in Candida albicans

FGS Silao, M Ward, K Ryman, A Wallström… - PLoS …, 2019 - journals.plos.org
Amino acids are among the earliest identified inducers of yeast-to-hyphal transitions in
Candida albicans, an opportunistic fungal pathogen of humans. Here, we show that the …

COVID-19-associated fungal infections in Iran: A systematic review

T Nazari, F Sadeghi, A Izadi, S Sameni, S Mahmoudi - PLoS One, 2022 - journals.plos.org
Objectives This systematic review aims to summarize the mycological and clinical features of
COVID-19-associated fungal infections (CAFIs) in Iran. Methods PubMed, Web of Science …

Oral Candida administration in a Clostridium difficile mouse model worsens disease severity but is attenuated by Bifidobacterium

W Panpetch, N Somboonna, M Palasuk, P Hiengrach… - PLoS …, 2019 - journals.plos.org
Gut fungi may influence the course of Clostridium difficile infection either positively or
negatively for the host. Fungi are not prominent in the mouse gut, and C. albicans, the major …

Control of β-glucan exposure by the endo-1,3-glucanase Eng1 in Candida albicans modulates virulence

M Yang, NV Solis, M Marshall, R Garleb, T Zhou… - PLoS …, 2022 - journals.plos.org
Candida albicans is a major opportunistic pathogen of humans. It can grow as
morphologically distinct yeast, pseudohyphae and hyphae, and the ability to switch …

Activation of Cph1 causes ß(1,3)-glucan unmasking in Candida albicans and attenuates virulence in mice in a neutrophil-dependent manner

AS Wagner, TJ Hancock, SW Lumsdaine… - PLoS …, 2021 - journals.plos.org
Masking the immunogenic cell wall epitope ß (1, 3)-glucan under an outer layer of
mannosylated glycoproteins is an important virulence factor deployed by Candida albicans …

Epitope unmasking in vulvovaginal candidiasis is associated with hyphal growth and neutrophilic infiltration

E Pericolini, S Perito, A Castagnoli, E Gabrielli… - PLoS …, 2018 - journals.plos.org
Vaginal candidiasis is a common disorder in women of childbearing age, caused primarily
by the dimorphic fungus Candida albicans. Since C. albicans is a normal commensal of the …

Stress- and metabolic responses of Candida albicans require Tor1 kinase N-terminal HEAT repeats

W Qi, M Acosta-Zaldivar, PR Flanagan, NN Liu… - PLoS …, 2022 - journals.plos.org
Whether to commit limited cellular resources toward growth and proliferation, or toward
survival and stress responses, is an essential determination made by Target of Rapamycin …

Cek1 regulates ß(1,3)-glucan exposure through calcineurin effectors in Candida albicans

AS Wagner, SW Lumsdaine, MM Mangrum… - PLoS …, 2022 - journals.plos.org
In order to successfully induce disease, the fungal pathogen Candida albicans regulates
exposure of antigens like the cell wall polysaccharide ß (1, 3)-glucan to the host immune …