Bisphenol A (BPA) is an organic synthetic compound serving as a monomer to produce
polycarbonate plastic, widely used in the packaging for food and drinks, medical devices …

Congenital heart disease (CHD) is one of the most common birth defects. Studies in animal
models and humans have indicated a genetic etiology for CHD. About 400 genes have been …

Organoids capable of forming tissue-like structures have transformed our ability to model
human development and disease. With the notable exception of the human heart, lineage …

Molecular profiling of single cells has advanced our knowledge of the molecular basis of
development. However, current approaches mostly rely on dissociating cells from tissues …

Organoids are powerful models for studying tissue development, physiology, and disease.
However, current culture systems disrupt the inductive tissue-tissue interactions needed for …

The heart is the central organ of the circulatory system, and its proper development is vital
for maintaining human life. Here, we used single-cell RNA sequencing to profile the gene …

Pluripotent stem cell-derived organoids can recapitulate significant features of organ
development in vitro. We hypothesized that creating human heart organoids by mimicking …

Developing technologies for efficient and scalable disruption of gene expression will provide
powerful tools for studying gene function, developmental pathways, and disease …

LV. 5, 9 The deep muscle fibers of the RV are longitudinally aligned base to apex. In contrast
to the RV, the LV contains obliquely oriented myofibers superficially, longitudinally oriented …

MicroRNAs (miRNAs) are genomically encoded small RNAs used by organisms to regulate
the expression of proteins generated from messenger RNA transcripts. The in vivo …