MRI has improved the diagnostic work-up of multiple sclerosis, but inappropriate image
interpretation and application of MRI diagnostic criteria contribute to misdiagnosis. Some …

In patients presenting with a clinically isolated syndrome, MRI can support and substitute
clinical information in the diagnosis of multiple sclerosis by showing disease dissemination …

Importance In multiple sclerosis (MS), chronic active lesions, which previously could only be
detected at autopsy, can now be identified on susceptibility-based magnetic resonance …

Recent data suggest that multiple sclerosis white matter lesions surrounded by a rim of iron
containing microglia, termed iron rim lesions, signify patients with more severe disease …

In the CNS, iron in several proteins is involved in many important processes such as oxygen
transportation, oxidative phosphorylation, myelin production, and the synthesis and …

In multiple sclerosis (MS), iron accumulates inside activated microglia/macrophages at
edges of some chronic demyelinated lesions, forming rims. In susceptibility-based magnetic …

The clinical use of MRI in patients with multiple sclerosis (MS) has advanced markedly over
the past few years. Technical improvements and continuously emerging data from clinical …

BACKGROUND. In some active multiple sclerosis (MS) lesions, a strong immune reaction at
the lesion edge may contain growth and thereby isolate the lesion from the surrounding …

This article provides a comprehensive overview of the pathology of multiple sclerosis (MS),
including recent insights into its molecular neuropathology and immunology. It shows that all …

Cortical lesions constitute an important part of multiple sclerosis pathology. Although
inflammation appears to play a role in their formation, the mechanisms leading to …