Tumor evolution presents a formidable obstacle that currently prevents the development of
truly curative treatments for cancer. In this perspective, we advocate for the hypothesis that …

Accurate chromosome segregation in mitosis is crucial to maintain a diploid chromosome
number. A majority of cancer cells are aneuploid and chromosomally unstable, ie they tend …

The many complex phenotypes of cancer have all been attributed to “somatic mutation.”
These phenotypes include anaplasia, autonomous growth, metastasis, abnormal cell …

Carcinogenesis is a multistep process in which new, parasitic and polymorphic cancer cells
evolve from a single, normal diploid cell. This normal cell is converted to a prospective …

Conventional genetic theories have failed to explain why cancer (1) is not heritable and thus
extremely rare in newborns,(2) is caused by non-mutagenic carcinogens,(3) develops only …

The mutation rates of cancer cells to drug and multidrug resistance are paradoxically high,
ie, 10− 3 to 10− 6, compared with those altering phenotypes of recessive genes in normal …

Goodbye, genetic blueprint.... The first book for general readers on the game-changing field
of epigenetics. The burgeoning new science of epigenetics offers a cornucopia of insights …

Unravelling the molecular mechanisms underlying gastric carcinogenesis is one of the
major challenges in cancer genomics. Gastric cancer is a very complex and heterogeneous …

Most of the current drugs used to treat cancer can be classified as anti-proliferative drugs.
These drugs perturb the proliferative cycle of tumor cells at diverse stages of the cell cycle …

Abnormal DNA content (aneuploidy) has been associated with malignant and premalignant
epithelial lesions. The presence of aneuploidy in tumours at an early stage and in dysplastic …