Nanoparticles (NPs) have been extensively investigated for applications in both
experimental and clinical settings to improve delivery efficiency of therapeutic and …

More than a century ago, independent groups raised the possibility of using bacteria to
selectively infect tumours. Such treatment induces an immune reaction that can cause …

Abstract The Mycobacterium bovis Bacille Calmette–Guerin cell wall skeleton (BCG-CWS)
could be used to replace live BCG as a bladder cancer drug. However, because BCG-CWS …

Nucleic acid (NA)-based therapies are revolutionizing biomedical research through their
ability to control cellular functions at the genetic level. This work demonstrates a versatile …

Bladder cancer is the sixth most common cancer in the United States, and it exhibits an
alarming 70% recurrence rate. Thus, the development of more efficient antibladder cancer …

Adhesion is crucial for the infective lifestyles of bacterial pathogens. Adhesion to non-living
surfaces, other microbial cells, and components of the biofilm extracellular matrix are crucial …

The hydrophobic composition of mycobacterial cell walls leads to the formation of clumps
when attempting to resuspend mycobacteria in aqueous solutions. Such aggregation may …

We previously reported on the development of a water soluble formulation of the cell wall
skeleton of BCG (BCG-CWS), a major immune active center of BCG, by encapsulating it into …

Background Bladder cancer is the fourth most common cancer in men and eleventh most
common in women. Combination therapy using a gene and chemotherapeutic drug is a …

A synthetic peptidolipopolymer conjugate, incorporated into liposomes to promote specific
binding to the fibronectin (FBN) matrix surrounding bladder tumor cells and promote cellular …