The neuroepithelial stem cell protein, or Nestin, is a cytoskeletal intermediate filament
initially characterized in neural stem cells. However, current extensive evidence obtained in …

Sphere-forming assays have been widely used to retrospectively identify stem cells based
on their reported capacity to evaluate self-renewal and differentiation at the single-cell level …

Targeting self-renewal is an important goal in cancer therapy and recent studies have
focused on Notch signalling in the maintenance of stemness of glioma stem cells (GSCs) …

The discovery of stem cells that can generate neural tissue has raised new possibilities for
repairing the nervous system. A rush of papers proclaiming adult stem cell plasticity has …

New neurons are generated in the adult hippocampus throughout life by neural
stem/progenitor cells (NSCs), and neurogenesis is a plastic process responsive to external …

Multipotent neural stem cells are present throughout the development of the central nervous
system (CNS), persist into adulthood in defined locations and can be derived from more …

Spinal cord injury often results in permanent functional impairment. Neural stem cells
present in the adult spinal cord can be expanded in vitro and improve recovery when …

To characterize the properties of adult neural stem cells (NSCs), we generated and
analyzed Sox2-GFP transgenic mice. Sox2-GFP cells in the subgranular zone (SGZ) …

Neural stem cells generate a wide spectrum of cell types in developing and adult nervous
systems. These cells are marked by expression of the intermediate filament nestin. We used …

Recent studies demonstrated the neuronogenic role of radial glial cells (RGCs) in the
rodent. To reveal the fate of radial glial processes, we intensively monitored divisions of …