Antimalarial drug resistance in Africa: the calm before the storm?

MD Conrad, PJ Rosenthal - The Lancet Infectious Diseases, 2019 - thelancet.com
Antimalarial drug resistance, in particular resistance to Plasmodium falciparum, challenges
the treatment and control of malaria. In this Review, we summarise evolving patterns of …

Antimalarial drug resistance and implications for the WHO global technical strategy

MM Ippolito, KA Moser, JBB Kabuya… - Current epidemiology …, 2021 - Springer
Abstract Purpose of Review Five years have passed since the World Health Organization
released its Global Technical Strategy for Malaria (GTS). In that time, progress against …

Overall, anti-malarial, and non-malarial effect of intermittent preventive treatment during pregnancy with sulfadoxine-pyrimethamine on birthweight: a mediation …

ME Roh, FO Ter Kuile, F Rerolle… - The Lancet Global …, 2020 - thelancet.com
Background Trials of intermittent preventive treatment (IPTp) of malaria in pregnant women
that compared dihydroartemisinin-piperaquine with the standard of care, sulfadoxine …

Geographical spread and structural basis of sulfadoxine-pyrimethamine drug-resistant malaria parasites

R Chaturvedi, J Chhibber-Goel, I Verma… - International Journal for …, 2021 - Elsevier
The global spread of sulfadoxine (Sdx, S) and pyrimethamine (Pyr, P) resistance is attributed
to increasing number of mutations in DHPS and DHFR enzymes encoded by malaria …

Recovery and stable persistence of chloroquine sensitivity in Plasmodium falciparum parasites after its discontinued use in Northern Uganda

B Balikagala, M Sakurai-Yatsushiro, SI Tachibana… - Malaria journal, 2020 - Springer
Background Usage of chloroquine was discontinued from the treatment of Plasmodium
falciparum infection in almost all endemic regions because of global spread of resistant …

A snapshot of the prevalence of dihydropteroate synthase-431V mutation and other sulfadoxine-pyrimethamine resistance markers in Plasmodium falciparum isolates …

AJ Adegbola, OA Ijarotimi, AE Ubom, BA Adesoji… - Malaria Journal, 2023 - Springer
Background Malaria is a major public health issue with substantial risks among vulnerable
populations. Currently, the World Health Organization (WHO) recommends SP-IPTp in the …

[HTML][HTML] School-aged children based seasonal malaria chemoprevention using artesunate-amodiaquine in Mali

MA Thera, AK Kone, B Tangara, E Diarra… - Parasite epidemiology …, 2018 - Elsevier
Introduction Malaria is still a public health problem in Africa. Seasonal Malaria
Chemoprevention (SMC) is an efficient control strategy recommended by WHO that targets …

Piperaquine-induced QTc prolongation decreases with repeated monthly dihydroartemisinin-piperaquine dosing in pregnant Ugandan women

E Hughes, E Wallender, R Kajubi… - Clinical Infectious …, 2022 - academic.oup.com
Background Intermittent preventive treatment with monthly dihydroartemisinin-piperaquine
(DHA-PQ) is highly effective at preventing both malaria during pregnancy and placental …

How has mass drug administration with dihydroartemisinin-piperaquine impacted molecular markers of drug resistance? A systematic review

S Moss, E Mańko, S Krishna, S Campino, TG Clark… - Malaria journal, 2022 - Springer
Abstract The World Health Organization (WHO) recommends surveillance of molecular
markers of resistance to anti-malarial drugs. This is particularly important in the case of mass …

Identifying an optimal dihydroartemisinin-piperaquine dosing regimen for malaria prevention in young Ugandan children

E Wallender, AM Ali, E Hughes, A Kakuru… - Nature …, 2021 - nature.com
Intermittent preventive treatment (IPT) with dihydroartemisinin-piperaquine (DP) is highly
protective against malaria in children, but is not standard in malaria-endemic countries …