While the immune system is essential for survival, an excessive or prolonged inflammatory
response, such as that resulting from sustained heavy alcohol use, can damage the host …

According to data from the World Health Organization, there were about 3 million deaths
caused by alcohol consumption worldwide in 2016, of which about 50% were related to liver …

Background and Aims Mitochondrial double‐stranded RNA (mtdsRNA) and its innate
immune responses have been reported previously; however, mtdsRNA generation and its …

Sepsis caused by Gram-negative bacteria is one of major causes for the progression of
acute lung injury (ALI) with limited treatment and effective medicines. Tabersonine is an …

Alcohol abuse can induce brain injury and neurodegeneration, and recent evidence shows
the participation of immune receptors toll-like in the neuroinflammation and brain damage …

For many individuals, first exposure to alcohol occurs either prenatally due to maternal
drinking, or during adolescence, when alcohol consumption is most likely to be initiated …

Background Aerobic glycolysis is a typical metabolic reprogramming in tumor cells, which
contributes to the survival and proliferation of tumor cells. The underlying mechanisms …

Alcohol Use Disorder (AUD) is a chronic, relapsing syndrome diagnosed by a
heterogeneous set of behavioral signs and symptoms. There are no laboratory tests that …

Acute lung injury (ALI) and its most severe form acute respiratory distress syndrome (ARDS)
caused by gram-positive bacteria threatens human life because effective treatments and …

Mechanisms underlying alcohol‐induced liver injury and its progression still remain
incompletely understood. Animal models can only address some aspects of the …