The carotid body (CB) is the main peripheral chemoreceptor for arterial respiratory gases O2
and CO2 and pH, eliciting reflex ventilatory, cardiovascular, and humoral responses to …

Heart failure (HF) is a complex clinical syndrome affecting roughly 26 million people
worldwide. Increased sympathetic drive is a hallmark of HF and is associated with disease …

Key points Heart failure with preserved ejection fraction (HFpEF) is associated with
disordered breathing patterns, and sympatho‐vagal imbalance. Although it is well accepted …

Chronic heart failure is characterized by autonomic imbalance, cardiac dysfunction, and
arrhythmogenesis. It has been shown that exercise training (ExT) improves central nervous …

Key points Carotid bodies play a critical role in maintaining arterial pressure during hypoxia
and this has important implications when considering resection therapy of the carotid body …

Key points Excitatory amino acid transporter 2 (EAAT2) is present on astrocytes in the
nucleus tractus solitarii (nTS), an important nucleus in cardiorespiratory control. Its specific …

Activation of the sympathetic nervous system is a hallmark of heart failure (HF) and is
positively correlated with disease progression. Catecholaminergic (C1) neurons located in …

Enhanced central chemoreflex (CC) gain is observed in volume overload heart failure (HF)
and is correlated with autonomic dysfunction and breathing disorders. The aim of this study …

Despite the plethora of current treatment options, hypertension remains a difficult condition
to adequately control, and there is a pressing need for novel therapeutic strategies. The …

Maintaining oxygen homeostasis is crucial to the survival of animals. Mammals respond
acutely to changes in blood oxygen levels by modulating cardiopulmonary function. The …