Children differ from adults in their response to drugs. While this may be the result of changes
in dose exposure (pharmacokinetics [PK]) and/or exposure response (pharmacodynamics …

The pharmacokinetics and pharmacodynamics of drugs are different in adult and paediatric
populations, the latter being particularly heterogeneous. These differences in …

Population pharmacokinetic models are used to describe the time course of drug exposure
in patients and to investigate sources of variability in patient exposure. They can be used to …

Pharmacokinetic/pharmacodynamic data are often analysed using nonlinear mixed-effect
models, and model evaluation should be an important part of the analysis. Recently …

In nonlinear mixed-effects models, estimation methods based on a linearization of the
likelihood are widely used although they have several methodological drawbacks. Kuhn and …

Pharmacokinetic (PK) and pharmacodynamic (PD) modeling and simulation (M&S) are well-
recognized powerful tools that enable effective implementation of the learn-and-confirm …

The study of medications among pediatric patients has increased worldwide since 1997 in
response to new legislation and regulations, but these studies have not yet adequately …

Nonlinear mixed effect models (NLMEM) with multiple responses are increasingly used in
pharmacometrics, one of the main examples being the joint analysis of the pharmacokinetics …

Inadequate dose selection for confirmatory trials is currently still one of the most challenging
issues in drug development, as illustrated by high rates of late‐stage attritions in clinical …

Taking readers from the research laboratory to the bedside, this Second Edition compiles
essential information on the pharmacodynamics of all major classes of the antimicrobial …