Electrophysiological mechanisms underlying T-wave alternans and their role in arrhythmogenesis

T You, C Luo, K Zhang, H Zhang - Frontiers in physiology, 2021 - frontiersin.org
T-wave alternans (TWA) reflects every-other-beat alterations in the morphology of the
electrocardiogram ST segment or T wave in the setting of a constant heart rate, hence, in the …

Applications of machine learning in ambulatory ECG

J Xue, L Yu - Hearts, 2021 - mdpi.com
Simple Summary The ambulatory ECG (AECG) is an important diagnostic tool for many
heart electrophysiology-related cases. This review covers some key Ambulatory ECG …

New directions in cardiac arrhythmia management: present challenges and future solutions

S Nattel, J Andrade, L Macle, L Rivard, K Dyrda… - Canadian Journal of …, 2014 - Elsevier
Cardiac arrhythmias are a major contributor to population morbidity and mortality. Enormous
advances in arrhythmia management have occurred over the 60 years since the founding of …

Machine Learning approach for TWA detection relying on ensemble data design

MG Fernández–Calvillo, R Goya–Esteban… - Heliyon, 2023 - cell.com
Background and objective T-wave alternans (TWA) is a fluctuation of the ST–T complex of
the surface electrocardiogram (ECG) on an every–other–beat basis. It has been shown to be …

Excitation-contraction coupling and calcium release in atrial muscle

LA Blatter, G Kanaporis, E Martinez-Hernandez… - … -European Journal of …, 2021 - Springer
In cardiac muscle, the process of excitation-contraction coupling (ECC) describes the chain
of events that links action potential induced myocyte membrane depolarization, surface …

Alternans in atria: Mechanisms and clinical relevance

G Kanaporis, LA Blatter - Medicina, 2017 - mdpi.com
Atrial fibrillation is the most common sustained arrhythmia and its prevalence is rapidly rising
with the aging of the population. Cardiac alternans, defined as cyclic beat-to-beat …

Utility of a smartphone based system (cvrPhone) to predict short-term arrhythmia susceptibility

K Sohn, SP Dalvin, FM Merchant, K Kulkarni, F Sana… - Scientific reports, 2019 - nature.com
Repolarization alternans (RA) has been implicated in the pathogenesis of ventricular
arrhythmias and sudden cardiac death. We developed a 12-lead, blue-tooth/Smart-Phone …

Action potential shortening rescues atrial calcium alternans

G Kanaporis, ZM Kalik, LA Blatter - The Journal of Physiology, 2019 - Wiley Online Library
Key points Cardiac alternans refers to a beat‐to‐beat alternation in contraction, action
potential (AP) morphology and Ca2+ transient (CaT) amplitude, and represents a risk factor …

Microvolt t-wave alternans is modulated by acute low-level tragus stimulation in patients with ischemic cardiomyopathy and heart failure

K Kulkarni, S Stavrakis, K Elkholey, JP Singh… - Frontiers in …, 2021 - frontiersin.org
Aims: Microvolt T-wave alternans (TWA), an oscillation in T-wave morphology of the
electrocardiogram (ECG), has been associated with increased susceptibility to ventricular …

Real-time closed-loop suppression of repolarization alternans reduces arrhythmia susceptibility in vivo

FM Merchant, O Sayadi, K Sohn, EH Weiss… - Circulation …, 2020 - Am Heart Assoc
Background: Repolarization alternans (RA) has been implicated in the pathogenesis of
ventricular arrhythmias and sudden cardiac death. Methods: We have developed a real …