Harnessing neuroplasticity: modern approaches and clinical future

AO Sasmita, J Kuruvilla, APK Ling - International Journal of …, 2018 - Taylor & Francis
Background and purpose: Neurological diseases and injuries to the nervous system may
cause inadvertent damage to neuronal and synaptic structures. Such phenomenon would …

[HTML][HTML] Aß pathology and neuron–glia interactions: A synaptocentric view

CFM Huffels, J Middeldorp, EM Hol - Neurochemical Research, 2023 - Springer
Alzheimer's disease (AD) causes the majority of dementia cases worldwide. Early
pathological hallmarks include the accumulation of amyloid-ß (Aß) and activation of both …

[HTML][HTML] CaMKII-Mediated CREB Phosphorylation Is Involved in Ca2+-Induced BDNF mRNA Transcription and Neurite Outgrowth Promoted by Electrical Stimulation

X Yan, J Liu, Z Ye, J Huang, F He, W Xiao, X Hu, Z Luo - PloS one, 2016 - journals.plos.org
Electrical stimulation (ES)-triggered up-regulation of brain-derived neurotrophic factor
(BDNF) and neurite outgrowth in cultured rat postnatal dorsal root ganglion neurons …

Brain‐derived neurotrophic factor stimulates proliferation and differentiation of neural stem cells, possibly by triggering the Wnt/β‐catenin signaling pathway

BY Chen, X Wang, ZY Wang, YZ Wang… - Journal of …, 2013 - Wiley Online Library
Brain‐derived neurotrophic factor (BDNF) has critical functions in promoting survival,
expansion, and differentiation of neural stem cells (NSCs), but its downstream regulation …

Resveratrol ameliorates chronic unpredictable mild stress-induced depression-like behavior: involvement of the HPA axis, inflammatory markers, BDNF, and Wnt/β …

XH Yang, SQ Song, Y Xu - Neuropsychiatric disease and treatment, 2017 - Taylor & Francis
Classic antidepressant drugs are modestly effective across the population and most are
associated with intolerable side effects. Recently, numerous lines of evidence suggest that …

Neurotrophin signaling and stem cells—implications for neurodegenerative diseases and stem cell therapy

S Pramanik, YA Sulistio, K Heese - Molecular neurobiology, 2017 - Springer
Neurotrophins (NTs) are members of a neuronal growth factor protein family whose action is
mediated by the tropomyosin receptor kinase (TRK) receptor family receptors and the p75 …

[HTML][HTML] The Three-Dimensional Culture System with Matrigel and Neurotrophic Factors Preserves the Structure and Function of Spiral Ganglion Neuron In Vitro

G Sun, W Liu, Z Fan, D Zhang, Y Han, L Xu, J Qi… - Neural …, 2016 - hindawi.com
Whole organ culture of the spiral ganglion region is a resourceful model system facilitating
manipulation and analysis of live sprial ganglion neurons (SGNs). Three-dimensional (3D) …

Brain-derived neurotrophic factor promotes growth of neurons and neural stem cells possibly by triggering the phosphoinositide 3-kinase/AKT/glycogen synthase …

X Li, Z Liang, T Wang, J Yang, W Ma… - CNS & Neurological …, 2017 - ingentaconnect.com
Background: Brain-derived neurotrophic factor (BDNF) plays a crucial role in promoting
survival and differentiation of neurons and neural stem cells (NSCs), but the downstream …

Cochlear afferent innervation development

L Delacroix, B Malgrange - Hearing Research, 2015 - Elsevier
Sound signal is detected by sensory hair cells located in the cochlear region of the inner ear,
and transmitted to the central nervous system by the spiral ganglion neurons (SGNs). These …

[HTML][HTML] Endothelial progenitor cells and neural progenitor cells synergistically protect cerebral endothelial cells from Hypoxia/reoxygenation-induced injury via …

J Wang, Y Chen, Y Yang, X Xiao, S Chen, C Zhang… - Molecular brain, 2016 - Springer
Background Protection of cerebral endothelial cells (ECs) from hypoxia/reoxygenation (H/R)-
induced injury is an important strategy for treating ischemic stroke. In this study, we …