Pyrazolopyrimidines are the fused heterocyclic ring systems which structurally resemble
purines which prompted biological investigations to assess their potential therapeutic …

Pyrazoles are considered privileged scaffolds in medicinal chemistry. Previous reviews have
discussed the importance of pyrazoles and their biological activities; however, few have …

Some pyrazolo [3, 4-d] pyrimidines, structurally related with allopurinol, a well known
xanthine oxidase inhibitor, clinically used in the therapy of gout, have also been reported as …

A series of new pyrazolo [3, 4-d] pyrimidine possessing 4-(1H-benzimidazol-2-yl)-
phenylamine moiety at C4 position and primary as well as secondary amines at C6 position …

In this study, new pyrazolopyrimidine derivatives were designed and evaluated for
anticancer activity. PIM-1 inhibitiory activity were measured for the most potent compounds …

Abstract The pyrazolo [3, 4‐d] pyrimidine core has received a lot of interest from the
medicinal chemistry community as a promising framework for drug design and discovery. It …

A novel series of 7, 7-diphenyl-1, 2-dihydroimidazo [2, 1-c][1, 2, 4] triazin-6 (7 H)-one 6a–h,
were easily prepared via reactions of novel 2-hydrazinyl-4, 4-diphenyl-1 H-imidazol-5 (4 H) …

The reaction of 5-amino-3-(arylamino)-1H-pyrazole-4-carboxamides 1a, b with
acetylacetone 2 and arylidenemalononitriles 5a–c yielded the pyrazolo [1, 5-a]-pyrimidine …

Several 2-unsubstituted thieno [2, 3-d] pyrimidines have been prepared from 2-
aminothiophene-3-carboxylic acid esters and their carbonitrile analogs. Some triazolo …

Abstract Pyrazolo [3, 4-d] pyrimidines are one of the most important classes of fused
heterocyclic compounds which exhibit a broad range of biological and medicinal properties …