Growing evidence suggests that the gut microbiota modulates the efficacy and toxicity of
cancer therapy, most notably immunotherapy and its immune-related adverse effects. The …

Microorganisms, including bacteria, viruses, fungi, and other eukaryotes, play critical roles in
human health. An altered microbiome can be associated with complex diseases …

Fungal microorganisms (mycobiota) comprise a small but immunoreactive component of the
human microbiome, yet little is known about their role in human cancers. Pan-cancer …

Summary The KRAS G12D mutation is present in nearly half of pancreatic adenocarcinomas
(PDAC). We investigated the effects of inhibiting the KRAS G12D mutant protein with …

The response to tumor-initiating inflammatory and genetic insults can vary among
morphologically indistinguishable cells, suggesting as yet uncharacterized roles for …

Although polymorphic microbiomes have emerged as hallmarks of cancer, far less is known
about the role of the intratumor mycobiome as living microorganisms in cancer progression …

Our understanding of how the microbiota affects the balance between response to and
failure of cancer treatment by modulating the tumour microenvironment and systemic …

The effect of gut bacteria on the response to immune checkpoint inhibitors (ICIs) has been
studied, but the relationship between fungi and ICI responses is not fully understood. Herein …

Current cancer immunotherapy predominately focuses on eliciting type 1 immune responses
fighting cancer; however, long-term complete remission remains uncommon,. A pivotal …

Myeloid cells are known to suppress antitumour immunity. However, the molecular drivers of
immunosuppressive myeloid cell states are not well defined. Here we used single-cell RNA …