Mitochondrion harbors its own DNA (mtDNA), which encodes many critical proteins for the
assembly and activity of mitochondrial respiratory complexes. mtDNA is packed by many …

Irrespective of the morphological features of end-stage cell death (that may be apoptotic,
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …

Mitochondrial DNA (mtDNA) escaping stressed mitochondria provokes inflammation via
cGAS-STING pathway activation and, when oxidized (Ox-mtDNA), it binds cytosolic NLRP3 …

The chemotherapeutic use of cisplatin is limited by its severe side effects. In this study, by
conducting different omics data analyses, we demonstrated that cisplatin induces cell death …

▪ Abstract Apoptosis, or programmed cell death, is involved in development, elimination of
damaged cells, and maintenance of cell homeostasis. Deregulation of apoptosis may cause …

A plethora of apoptotic stimuli converge on the mitochondria and affect their membrane
integrity. As a consequence, multiple death-promoting factors residing in the mitochondrial …

Phagosome maturation is the process by which internalized particles (such as bacteria and
apoptotic cells) are trafficked into a series of increasingly acidified membrane-bound …

Human retinal dystrophies and degenerations and light-induced retinal degenerations in
animal models are sharing an important feature: visual cell death by apoptosis. Studying …

The major challenge in treating cancer is that many tumor cells carry mutations in key
apoptotic genes such as p53, Bcl family proteins or those affecting caspase signaling. Such …

Different cell-death mechanisms control many physiological and pathological processes in
humans. Mitochondria play important roles in cell death through the release of pro-apoptotic …