Mitochondria are ubiquitous intracellular organelles found in almost all eukaryotes and
involved in various aspects of cellular life, with a primary role in energy production. The …

The current state of knowledge on how copper metallochaperones support the maturation of
cuproproteins is reviewed. Copper is needed within mitochondria to supply the CuA and …

Biological copper is coordinated predominantly by just three ligand types: the side chains of
histidine, cysteine, and methionine, with of course some exceptions. The arrangement of …

Mitochondria import many hundreds of different proteins that are encoded by nuclear genes.
These proteins are targeted to the mitochondria, translocated through the mitochondrial …

All living organisms require nutrient minerals for growth and have developed mechanisms to
acquire, utilize, and store nutrient minerals effectively. In the aqueous cellular environment …

It has been estimated that about 90% of the reduction of molecular oxygen in the biosphere
is catalyzed by respiratory oxidases (95). Much of this is accomplished by a wide variety of …

Biogenesis of respiratory cytochromes is defined as consisting of the posttranslational
processes that are necessary to assemble apoprotein, heme, and sometimes additional …

Copper is required within the mitochondrion for the function of two metalloenzymes,
cytochrome c oxidase (CcO) and superoxide dismutase (Sod1). Copper metallation of these …

The coevolution of DNA binding proteins and their cognate binding sites is essential for the
maintenance of function. As a result, comparison of DNA binding proteins of unknown …

Metals are essential elements of all living organisms. Among them, copper is required for a
multiplicity of functions including mitochondrial oxidative phosphorylation and protection …