Spanlastics a novel nanovesicular carrier: its potential application and emerging trends in therapeutic delivery

MD Ansari, Z Saifi, J Pandit, I Khan, P Solanki… - AAPS …, 2022 - Springer
Nanotechnology-based drug delivery system has played a very crucial role in overpowering
the tasks allied with the conventional dosage form. Spanlastics, an elastic nanovesicle with …

Breakthroughs and bottlenecks of psoriasis therapy: Emerging trends and advances in lipid based nano-drug delivery platforms for dermal and transdermal drug …

S Singh, R Awasthi - Journal of Drug Delivery Science and Technology, 2023 - Elsevier
Psoriasis is a chronic autoimmune skin disease characterised by abnormal epidermal
keratinocytes, hyperproliferation, and inflammatory infiltration. The main challenges that …

Evaluation of metformin hydrochloride tailoring bilosomes as an effective transdermal nanocarrier

HF Salem, MM Nafady, AA Ali, NM Khalil… - International Journal of …, 2022 - Taylor & Francis
Introduction Metformin hydrochloride (metformin HCL), a first-line drug treating diabetes type
II, was known to cause severe gastritis, so seeking a non-oral dosage form was the new …

Formulation and optimization of nanospanlastics for improving the bioavailability of green tea epigallocatechin gallate

EA Mazyed, DA Helal, MM Elkhoudary… - Pharmaceuticals, 2021 - mdpi.com
The present study aimed to investigate the potential of nanospanlastics for boosting the
bioavailability of epigallocatechin gallate (EGCG). EGCG has valuable effects like anti …

Spanlastics as a potential approach for enhancing the nose-to-brain delivery of piperine: In vitro prospect and in vivo therapeutic efficacy for the management of …

I Gupta, SN Adin, MA Rashid, Y Alhamhoom, M Aqil… - Pharmaceutics, 2023 - mdpi.com
The present study delineates the preparation of piperine-loaded spanlastics (PIP-SPL) to
improve piperine (PIP) solubility, bioavailability, and permeation through nasal mucosa for …

Wound healing efficacy of rosuvastatin transethosomal gel, I optimal optimization, histological and in vivo evaluation

RM Zaki, VD Seshadri, AS Mutayran, LA Elsawaf… - Pharmaceutics, 2022 - mdpi.com
This study aimed to make a formulation and statistical optimization of transethosomal
formulations of rosuvastatin (ROS) to enhance its topical wound healing efficiency. Design …

[HTML][HTML] Spanlastic-laden in situ gel as a promising approach for ocular delivery of Levofloxacin: In-vitro characterization, microbiological assessment, corneal …

OA Agha, GNS Girgis, MMA El-Sokkary… - International Journal of …, 2023 - Elsevier
The objective of this study was to encapsulate the antibacterial drug levofloxacin
hemihydrate (LF) into spanlastics (SLs) followed by incorporation into gelrite in situ gel to …

Spanlastic nanovesicles for enhanced ocular delivery of vanillic acid: design, in vitro characterization, and in vivo anti-inflammatory evaluation

SS Ibrahim, H Abd-Allah - International Journal of Pharmaceutics, 2022 - Elsevier
Spanlastics are novel surfactant-based, elastic vesicular nanocarriers composed of spans
and edge activators. The present work aims to exploit their special penetration enhancing …

Formulation and characterization of quercetin-loaded Prunus armeniaca gum nanoparticles with enhanced anti-bacterial effect

EA Mazyed, G Magdy, E Elekhnawy… - Journal of Drug Delivery …, 2024 - Elsevier
Owing to the dissemination of antibiotic resistance among Staphylococcus aureus bacteria,
it is critical to find out new, safe, and effective alternatives. Plants are a major source of many …

3-Acetyl-11-keto-β-boswellic acid-based hybrids alleviate acetaminophen-induced hepatotoxicity in HepG2 by the regulation of inflammatory and oxidative stress …

AA Elgazar, RA El-Domany, WM Eldehna… - ACS omega, 2023 - ACS Publications
In an effort to develop new compounds for managing drug-induced liver injury, we prepared
23 novel hybrids based on 3-acetyl-11-keto-β-boswellic acid (AKBA) using various …