This white paper provides updated International Transporter Consortium (ITC)
recommendations on transporters that are important in drug development following the 3rd …

Transporters in proximal renal tubules contribute to the disposition of numerous drugs.
Furthermore, the molecular mechanisms of tubular secretion have been progressively …

Drug transporters can govern the absorption, distribution, metabolism, and excretion of
substrate drugs and endogenous substances. Investigations to examine their potential …

Metformin, widely used as first-line treatment for type 2 diabetes, exists primarily as a
hydrophilic cation at physiological pHs. As such, membrane transporters play a substantial …

Drug transporters play an essential role in disposition and effects of multiple drugs. Plasma
concentrations of the victim drug can be modified by drug–drug interactions occurring in …

This white paper examines recent progress, applications, and challenges in predicting
unbound and total tissue and intra/subcellular drug concentrations using in vitro and …

Introduction: Organic cation transporters collectively called OCTs belong to three gene
families (SLC22A1 OCT1, SLC22A2 OCT2, SLC22A3 OCT3, SLC22A4 OCTN1, SLC22A5 …

Transporter‐mediated drug‐drug interactions (DDIs) are a major cause of drug toxicities.
Using published genome‐wide association studies (GWAS) of the human metabolome, we …

Transporters govern the access of molecules to cells or their exit from cells, thereby
controlling the overall distribution of drugs to their intracellular site of action. Clinically …

In humans, creatinine is formed by a multistep process in liver and muscle and eliminated
via the kidney by a combination of glomerular filtration and active transport. Based on …