The somatosensory system decodes a wide range of tactile stimuli and thus endows us with
a remarkable capacity for object recognition, texture discrimination, sensory-motor feedback …

Neuropathic pain can develop after nerve injury, when deleterious changes occur in injured
neurons and along nociceptive and descending modulatory pathways in the central nervous …

Pain results from the activation of a subset of sensory neurones termed nociceptors and has
evolved as a “detect and protect” mechanism. However, lesion or disease in the sensory …

Central sensitization represents an enhancement in the function of neurons and circuits in
nociceptive pathways caused by increases in membrane excitability and synaptic efficacy as …

The original formulation of Gate Control Theory (GCT) proposed that the perception of pain
produced by spinal cord signaling to the brain depends on a balance of activity generated in …

Comorbid depression and chronic pain are highly prevalent in individuals suffering from
physical illness. Here, we critically examine the possibility that inflammation is the common …

Neurons in the spinal dorsal horn process sensory information, which is then transmitted to
several brain regions, including those responsible for pain perception. The dorsal horn …

Hyperalgesia and allodynia are frequent symptoms of disease and may be useful
adaptations to protect vulnerable tissues. Both may, however, also emerge as diseases in …

Modern pain-control theory predicts that a loss of inhibition (disinhibition) in the dorsal horn
of the spinal cord is a crucial substrate for chronic pain syndromes. However, the nature of …

The two amino acids GABA and glycine mediate fast inhibitory neurotransmission in different
CNS areas and serve pivotal roles in the spinal sensory processing. Under healthy …