Animal models for COVID-19: advances, gaps and perspectives

C Fan, Y Wu, X Rui, Y Yang, C Ling, S Liu… - Signal transduction and …, 2022 - nature.com
Abstract COVID-19, caused by SARS-CoV-2, is the most consequential pandemic of this
century. Since the outbreak in late 2019, animal models have been playing crucial roles in …

Advances and gaps in SARS-CoV-2 infection models

C Muñoz-Fontela, L Widerspick, RA Albrecht… - PLoS …, 2022 - journals.plos.org
The global response to Coronavirus Disease 2019 (COVID-19) is now facing new
challenges such as vaccine inequity and the emergence of SARS-CoV-2 variants of concern …

SARS-CoV-2 infection induces ferroptosis of sinoatrial node pacemaker cells

Y Han, J Zhu, L Yang, BE Nilsson-Payant… - Circulation …, 2022 - Am Heart Assoc
Background: Increasing evidence suggests that cardiac arrhythmias are frequent clinical
features of coronavirus disease 2019 (COVID-19). Sinus node damage may lead to …

Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in mice

AA Ordonez, CK Bullen, AF Villabona-Rueda… - Communications …, 2022 - nature.com
Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the cause of
coronavirus disease 2019 (COVID-19), has incited a global health crisis. Currently, there are …

A bacterial extracellular vesicle‐based intranasal vaccine against SARS‐CoV‐2 protects against disease and elicits neutralizing antibodies to wild‐type and Delta …

L Jiang, TAP Driedonks, WSP Jong… - Journal of …, 2022 - Wiley Online Library
Several vaccines have been introduced to combat the coronavirus infectious disease‐2019
(COVID‐19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS …

Hamster models of COVID-19 pneumonia reviewed: How human can they be?

AD Gruber, TC Firsching, J Trimpert… - Veterinary …, 2022 - journals.sagepub.com
The dramatic global consequences of the coronavirus disease 2019 (COVID-19) pandemic
soon fueled quests for a suitable model that would facilitate the development and testing of …

The SARS-CoV-2 spike protein binds and modulates estrogen receptors

O Solis, AR Beccari, D Iaconis, C Talarico… - Science …, 2022 - science.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein binds
angiotensin-converting enzyme 2 as its primary infection mechanism. Interactions between …

Guardians of the oral and nasopharyngeal galaxy: IgA and protection against SARS‐CoV‐2 infection

S Sheikh‐Mohamed, EC Sanders… - Immunological …, 2022 - Wiley Online Library
In early 2020, a global emergency was upon us in the form of the coronavirus disease 2019
(COVID‐19) pandemic. While horrific in its health, social and economic devastation, one …

Renin-angiotensin system and sex differences in COVID-19: a critical assessment

MC Chappell - Circulation Research, 2023 - Am Heart Assoc
The current epidemic of corona virus disease (COVID-19) has resulted in an immense
health burden that became the third leading cause of death and potentially contributed to a …

Infectious SARS-CoV-2 is emitted in aerosol particles

SA Hawks, AJ Prussin, SC Kuchinsky, J Pan, LC Marr… - MBio, 2021 - Am Soc Microbiol
Respiratory viruses such as SARS-CoV-2 are transmitted in respiratory droplets and aerosol
particles, which are released during talking, breathing, coughing, and sneezing. Noncontact …