Colorectal cancer in Iran: molecular epidemiology and screening strategies

R Dolatkhah, MH Somi, MJ Bonyadi… - Journal of cancer …, 2015 - Wiley Online Library
Purpose. The increasing incidence of colorectal cancer (CRC) in the past three decades in
Iran has made it a major public health burden. This study aimed to report its epidemiologic …

Clinical, pathologic, and molecular features of early-onset colorectal carcinoma

RK Yantiss, M Goodarzi, XK Zhou… - The American journal …, 2009 - journals.lww.com
The incidence of colorectal carcinoma has increased among patients< 40 years of age for
unclear reasons. In this study, we describe the clinical, pathologic, and molecular features of …

Wild-type and mutant p53 mediate cisplatin resistance through interaction and inhibition of active caspase-9

JLY Chee, S Saidin, DP Lane, SM Leong, JE Noll… - Cell Cycle, 2013 - Taylor & Francis
The p53 gene has been implicated in many cancers due to its frequent mutations as well as
mutations in other genes whose proteins directly affect p53's functions. In addition, high …

Differences of protein expression profiles, KRAS and BRAF mutation, and prognosis in right-sided colon, left-sided colon and rectal cancer

XH Gao, GY Yu, HF Gong, LJ Liu, Y Xu, LQ Hao… - Scientific Reports, 2017 - nature.com
To compare protein expression levels, gene mutation and survival among Right-Sided
Colon Cancer (RSCC), Left-Sided Colon Cancer (LSCC) and rectal cancer patients, 57 …

Genetic and molecular origins of colorectal Cancer among the Iranians: an update

MR Abbaszadegan, M Moghbeli - Diagnostic pathology, 2018 - Springer
Background Colorectal cancer (CRC) is one the leading causes of cancer related deaths
among Iranians. Despite the various progresses in new therapeutic methods, it has still a …

Folate and vitamin B6 intake and risk of colon cancer in relation to p53 expression

ES Schernhammer, S Ogino, CS Fuchs - Gastroenterology, 2008 - Elsevier
Background & Aims: Considerable evidence suggests that a low-folate diet increases the
risk of colorectal cancer, although the results of a recent randomized trial indicate that folate …

Hedgehog G li3 activator signal augments tumorigenicity of colorectal cancer via upregulation of adherence‐related genes

H Iwasaki, K Nakano, K Shinkai, Y Kunisawa… - Cancer …, 2013 - Wiley Online Library
Hedgehog signal is re‐activated in several cancers. In this study, we examined the role of
Gli3 on malignant phenotype of tumorigenicity for colorectal cancer and its relationship with …

Discovering the molecular differences between right-and left-sided colon cancer using machine learning methods

Y Jiang, X Yan, K Liu, Y Shi, C Wang, J Hu, Y Li, Q Wu… - BMC cancer, 2020 - Springer
Background In recent years, the differences between left-sided colon cancer (LCC) and right-
sided colon cancer (RCC) have received increasing attention due to the clinicopathological …

[PDF][PDF] The correlation between the immunostains for p53 and Ki67 with bcl-2 expression and classical prognostic factors in colorectal carcinomas

S Gurzu, J Jung, T Mezei, Z Pavai - Rom J Morphol Embryol, 2007 - rjme.ro
The prognostic role of p53 and Ki67 in colorectal carcinomas (CRC) is very controversial in
the literature. In our study, we tried to find if their immunostains are correlated with bcl-2 …

[PDF][PDF] 不同组织学类型结直肠腺癌的临床病理和免疫组织化学特征

裴笑月, 胡波, 吕玲, 李晓慧 - 临床与病理杂志, 2020 - cdn.amegroups.cn
目的: 探讨不同组织学类型结直肠腺癌的临床病理及免疫组织化学特征. 方法:
收集临床资料完善的结直肠腺癌292 例, 免疫组织化学SP 法检测所有肿瘤组织中突变型p53 …